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Analysis of risk factors for Tuberculosis Recurrence using a population-based TB/HIV integrated surveillance database in Chiang Rai, Thailand Open Access


Other title
risk factors
recurrence rate
Tuberculosis recurrence
Type of item
Degree grantor
University of Alberta
Author or creator
Wu, Xuan
Supervisor and department
Yasui, Yutaka (Public Health Sciences)
Examining committee member and department
Kipp, Walter (Public Health Sciences)
Houston, Stanley (Faculty of Medicine and Dentistry)
Public Health Sciences

Date accepted
Graduation date
Master of Science
Degree level
TB recurrence is defined as a new episode of bacteriologically positive TB in a patient previously declared “successfully completed treatment.” Our study objective was to identify risk factors of recurrence among HIV-infected and HIV-uninfected TB patients. Based on a population-based TB/HIV surveillance database of Chiang Rai Province, Thailand, a retrospective cohort of TB patients with successful completions of treatment between 1997 and 2008 was constructed. Poisson regression was used to model independent effects of risk factors. TB recurrence rates were 5.4/1,000 PYs and 9.7/1,000 PYs for HIV-uninfected and infected TB patients, respectively. We identified that among HIV-uninfected patients, older age, being hilltribe, being prisoners, were at higher risk of recurrence. While among HIV-infected patients, younger age, being male, and having been cured from initial episode were associated with higher recurrence rates. Targeted, practical preventive and treatment strategies for those patients need to be implemented to lower the TB recurrence rates.
License granted by Xuan Wu ( on 2010-12-09T21:43:20Z (GMT): Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of the above terms. The author reserves all other publication and other rights in association with the copyright in the thesis, and except as herein provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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