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Fluorescent-Core Microcapillaries: Detection Limits for Biosensing Applications Open Access


Other title
refractometric sensor
silicon quantum dots
whispering gallery modes
microfluidic biosensor
Type of item
Degree grantor
University of Alberta
Author or creator
McFarlane, Shalon A
Supervisor and department
Meldrum, Al (Physics)
Examining committee member and department
Van, Vien (Electrical & Computing Engineering)
Beach, Kevin (Physics)
Woodside, Michael (Physics)
Department of Physics

Date accepted
Graduation date
Master of Science
Degree level
This work develops a refractive-index sensor based on whispering gallery modes (WGMs) in glass microcapillaries. The capillary channel is coated with a layer of fluorescent silicon quantum dots (QDs), which provides a fluorescence source that also supports the WGMs. When different fluids are pumped into the channel, the fluorescence spectrum responds as the resonances shift to different frequencies. A study of the WGM spectral shift analysis techniques improved the detection limits to 10^-4 refractive index units, and permitted the development of sensorgram-type analyses in which the channel fluid is probed continuously in time. The feasibility of the device as a microfluidic biosensor was demonstrated by first functionalizing the silica surface and then detecting the binding of biotin and streptavidin to the capillary channel. These structures could be attractive as microfluidic biological sensors, since they are easy to fabricate, mechanically robust, and relatively inexpensive compared to other technologies.
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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