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Exploring the Use of Nuclear Magnetic Resonance to Examine Spinal Cord Injury
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- Author / Creator
- Hallihan, Daniel P
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Spinal cord injury is most commonly caused by physical
trauma, and the resulting functional loss can vary considerably in
both degree, extent and location.
Understanding what spinal
cord tissue is damaged and to what degree can be useful in both
determining the appropriate treatment for individuals with spinal
cord injury and for assessing novel methods of treatment. This
thesis looks at the applications of nuclear magnetic resonance
(NMR), to assess spinal cord injury, assess the effects of various
treatments and assist in developing new treatments of spinal
cord injury. The treatment of interest in this thesis is intra-spinal
micro-stimulation (ISMS), a method of functional electrical
stimulation (FES).
Magnetic resonance imaging (MRI) provided
grey/white matter contrast in images and ISMS micro-wire
localization, water compartmentalization showed promise in
determining
myelination,
and
nuclear
magnetic
resonance
spectroscopy (MRS) found several metabolites that varied due to
spinal cord injury and could potentially be measured in-vivo. -
- Subjects / Keywords
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- Graduation date
- Spring 2013
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- Type of Item
- Thesis
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- Degree
- Master of Science
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- License
- This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.