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Influences of grain boundaries and surface nanocrystallization of stainless Steel on Pseudomonas Aeruginosa Biofilm’s Adherence Open Access


Other title
Grain boundaries
Surface Nanocrystallization
Type of item
Degree grantor
University of Alberta
Author or creator
Yu, Bin
Supervisor and department
Dongyang Li, Department of Chemical and Materials Engineering, Department of Biomedical Engineering
Randall T. Irvin, Department of Microbiology and Immunology
Examining committee member and department
Randall T. Irvin, Department of Microbiology and Immunology
Larry Unsworth, Deapartment of Chemical and Materials Engineering, Biomedical Engineering
Dongyang Li, Department of Chemical and Materials Engineering
Department of Biomedical Engineering

Date accepted
Graduation date
Master of Science
Degree level
A common complication associated with medical implants is the infectious bio-film, which can cause chronic infection that is difficult to control. Grain boundaries (GBs) in materials of medical implants are often preferential locations for bacteria to congregate, which could be attributed to higher affinity of grain boundaries for bacterial bio-films. In this study, the molecular interaction of the Pseudomonas aeruginosa receptor binding domain, a self-folding domain of 17 amino acid residues derived for the PilA structural protein, which can represents properties of Pseudomonas aerginosa biofilm, with microcrystalline stainless steel surfaces was examined with atomic force microscopy (AFM) both at grain boundaries and within grains. Adherence of Pseudomonas aeruginosa biofilm to nanocrystallized stainless steel surface was also determined using AFM. Results indicate that adherence of biofilm’ adherence at grain boundaries of microcrystalline surface is 2-fold higher than that of inside grains. Nanocrytalline surface is more resistant to biofilm than the microcrystalline one due to the formation of a strong oxidation film after annealing and thermal oxidation process. Surface nanocrystallization for enhanced corrosion resistance of Ag-incorporated 304 stainless steel surface was also studied. It is demontstrated that nanocrystallization of the antibacterial agent-incorporated stainless steel surface also provides an effective approach to control the corrosion problem resulting from the typical galvanic effect of multiphase alloys.
License granted by Bin Yu ( on 2010-11-29T16:38:42Z (GMT): Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of the above terms. The author reserves all other publication and other rights in association with the copyright in the thesis, and except as herein provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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