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Theses and Dissertations
This collection contains theses and dissertations of graduate students of the University of Alberta. The collection contains a very large number of theses electronically available that were granted from 1947 to 2009, 90% of theses granted from 2009-2014, and 100% of theses granted from April 2014 to the present (as long as the theses are not under temporary embargo by agreement with the Faculty of Graduate and Postdoctoral Studies). IMPORTANT NOTE: To conduct a comprehensive search of all UofA theses granted and in University of Alberta Libraries collections, search the library catalogue at www.library.ualberta.ca - you may search by Author, Title, Keyword, or search by Department.
To retrieve all theses and dissertations associated with a specific department from the library catalogue, choose 'Advanced' and keyword search "university of alberta dept of english" OR "university of alberta department of english" (for example). Past graduates who wish to have their thesis or dissertation added to this collection can contact us at erahelp@ualberta.ca.
Items in this Collection
- 377Faculty of Pharmacy and Pharmaceutical Sciences
- 4Faculty of Medicine
- 2Faculty of Medicine and Oral Health Sciences
- 1Department of Biomedical Engineering
- 1Department of Medical Sciences
- 1Department of Medicine
- 1AL Omair, Omar Abdulrahman
- 1AL-AGILI, MARWA
- 1Abbasi Dezfouli, Saba
- 1Abdelmoneim, AS
- 1Abdulsalam Alharbi
- 1Abdussalam, Ali MA
- 15Pharmacokinetics
- 10Cytochrome P450
- 6Cancer
- 6Monoclonal antibodies
- 6Polymeric micelles
- 5Arachidonic acid
- 8El-Kadi, Ayman (Faculty of Pharmacy and Pharmaceutical Sciences)
- 6El-Kadi, Ayman (Pharmacy and Pharmaceutical Sciences)
- 6Lavasanifar, Afsaneh (Faculty of Pharmacy and Pharmaceutical Sciences)
- 5Brocks, Dion (Pharmacy and Pharmaceutical Sciences)
- 5Yuksel, Nese (Faculty of Pharmacy and Pharmaceutical Sciences)
- 4Doschak, Michael (Pharmacy and Pharmaceutical Sciences)
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Development of Novel Models to Study Sub and Post Cellular Uptake of Drugs Following Oral Administration
DownloadFall 2024
Given the numerous benefits of oral administration, this thesis investigates two key phenomena influencing the pharmacokinetics and pharmacodynamics of orally administered active pharmaceutical ingredients (APIs): lysosomal trapping and intestinal lymphatic uptake via chylomicrons, with a...
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Development of Novel Polymeric Micellar DACHPt for Enhanced Platinum Based Chemotherapy in Colorectal Cancer
DownloadSpring 2019
One of the major limitations of chemotherapy in cancer treatment is the side effects of anti-cancer drugs. This happens due to non-selective distribution of most standard chemotherapies, and their action on cancer and all normal dividing cells. The objective of this project is to develop a novel...
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Spring 2014
In this thesis, novel pH and temperature responsive polymers based on triblock of poly(ethylene glycol) (PEG) and functionalized poly(ε-caprolacton) having different levels of carboxyl to benzyl carboxylate on the α-carbon of caprolacton units (0:100, 30:70, 50:50, 100:0) were synthesized. The...
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Development of Poly(ethylene oxide)-block-poly(ε-caprolactone) based Micelles for Tumor Targeted Drug and siRNA Delivery
DownloadFall 2015
The use of nanotechnology has made significant advancements in cancer diagnosis and treatment. Polymeric micelles are a relatively new generation of nanocarriers mostly intended for the delivery of hydrophobic drugs. In this thesis, our objective was to develop an optimized polymeric micellar...
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Development of polymer and lipid based nano-delivery systems for targeted cancer chemotherapy
DownloadFall 2012
Conventional chemotherapy agents can kill tumor cells and inhibit tumor growth, but they produce severe side effects on normal cells at the same time. To shift the balance towards tumoral effects, it would be desirable to direct the anti-cancer drug towards tumor while restricting drug access to...
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Development of Polymeric Micelles for Site Specific Delivery of Nonsteroidal Anti-Inflammatory Drugs: Effect on the Cardiovascular Risk in an Experimental Model of Arthritis
DownloadFall 2019
Non-steroidal anti-inflammatory drugs (NSAIDs), which inhibit cyclooxygenase (COX) enzymes, are among the most widely used medications worldwide with proven efficacy in controlling inflammation and pain associated various disease conditions. The chronic systemic use of most NSAIDs, however, is...
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Fall 2010
In many tumors, persistently-active signal transducer and activator of transcription 3 (STAT3) imparts several oncogenic features such as survival, proliferation, angiogenesis, and immune escape. Therefore, STAT3 targeting in cancer and cancer-exposed dendritic cells (DCs) is important for cancer...
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Development of traceable Rituximab modified polymeric micelles for active targeting of B-cell Lymphoma
DownloadFall 2017
Abstract B-cell Non-Hodgkin Lymphoma (NHL) accounts for more than 90% of all adult cases of lymphomas and in most cases it is CD20 positive. B-cell NHL is usually treated by combination of conventional chemotherapeutics and the monoclonal antibody against CD20, rituximab. This combination regimen...
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Fall 2015
Several studies have examined the toxic effects of individual aryl hydrocarbon receptor (AhR) ligands, yet there are relatively few reports of the combined toxic effects of AhR ligands and other environmental co-contaminants, such as heavy metals. Chromium (Cr+6) is one of the major environmental...