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Journal Articles (Biochemistry)
Items in this Collection
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COUP-TF1 antagonizes Nkx25-mediated activation of the calreticulin gene during cardiac development
Download2001-01-01
Guo, Lei, Lynch, Jeffrey, Nakamur, Kimitoshi, Fliegel, Larry, Kasahara, Hideko, Izumo, Seigo, Komuro, Issei, Agellon, Luis B., Michalak, Marek
Calreticulin, a Ca2+ binding chaperone of the endoplasmic reticulum, is also highly expressed in the embryonic heart, and knockout of the calreticulin gene is lethal during embryogenesis because of impaired cardiac development. The protein is down-regulated after birth, and elevated expression of...