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Department of Pediatrics

The Department of Pediatrics at the University of Alberta is dedicated to the advancement of child health through the delivery of exemplary patient care, teaching, and research. The department contributes to and advocates for the child health community through a network of pediatric physicians, scientists, educators, nurses and allied health professionals. With a cohort of over 130 academic staff, across 20 clinical specializations, the department fosters a strong environment of multi-disciplinary collaboration and teamwork. Critical ties to community, provincial, national and international colleagues further promote and expand the department's boundaries in innovation and discovery.
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  1. A Spatial Scan Statistic for Compound Poisson Data, Using Negative Binomial Distribution and Accounting for Population Stratification [Download]

    Title: A Spatial Scan Statistic for Compound Poisson Data, Using Negative Binomial Distribution and Accounting for Population Stratification
    Creator: Chang, Hsing-Ming
    Description: Since the interest in studying spatial relations in plant populations was raised in the 1950s, much effort has been devoted to the development of methods for spatial data analysis. One such development focused on techniques for detecting spatial clusters of cases and events in the biological sciences and epidemiology during the late 1980s and the following decade. More recently, research has examined detecting clusters of correlated count data associated with health conditions of individuals. Such a method allows researchers to examine spatial relationships of disease-related events rather than just incidents or prevalent cases. We introduce a spatial scan test that identifies clusters of events in a study region. Because an individual case may have multiple (repeated) events, we base the test on a special compound Poisson model. Based on this special class (a compound Poisson representation of the negative binomial distribution), advantages in computation over the general compound Poisson model that relies on a recursive formula are realized. We illustrate our method for cluster detection on emergency department visits, where individuals may make multiple asthma-related visits. We also demonstrate the spatial scan test adjusted by key population characteristics such as sex or age.
    Subjects: spatial scan, stratification, compound Poisson, surveillance, negative binomial, cluster detection
  2. Hierarchical Bayesian Spatio-Temporal Analysis of Childhood Cancer Trends [Download]

    Title: Hierarchical Bayesian Spatio-Temporal Analysis of Childhood Cancer Trends
    Creator: Torabi, Mahmoud
    Description: In this paper, generalized additive mixed models are constructed for the analysis of geographical and temporal variability of cancer ratios. In this class of models, spatially correlated random effects and temporal components are adopted. Spatio-temporal models that use intrinsic conditionally autoregressive smoothing across the spatial dimension and B-spline smoothing over the temporal dimension are considered. We study the patterns of incidence ratios over time and identify areas with consistently high ratio estimates as areas for further investigation. A hierarchical Bayesian approach using Markov chain Monte Carlo techniques is employed for the analysis of the childhood cancer diagnoses in the province of Alberta, Canada during 1995-2004. We also evaluate the sensitivity of such analyses to prior assumptions in the Poisson context.
    Subjects: spatio-temporal models, hierarchical Bayesian, childhood cancer
  3. Emergency Medicine

    Title: Emergency Medicine
    Creator: ERA Administrator
    Description: Pediatricians from the Department of Pediatrics and Alberta Health Services has collaborated and have helped create the only sub-specialized Pediatric Emergency Department, which engages in knowledge exchange and training with healthcare professionals across Alberta.
    Subjects:
  4. Environmental Health

    Title: Environmental Health
    Creator: ERA Administrator
    Subjects:
  5. Acyclovir for treating varicella in otherwise healthy children and adolescents [Download]

    Title: Acyclovir for treating varicella in otherwise healthy children and adolescents
    Creator: Klassen TP
    Subjects: Chickenpox, Antiviral Agents, Acyclovir, Adolescent, Randomized Controlled Trials as Topic
    Date Created: 2005
  6. Sulfasalazine for treating rheumatoid arthritis [Download]

    Title: Sulfasalazine for treating rheumatoid arthritis
    Creator: Suarez-Almazor ME
    Subjects: Sulfasalazine, Non-Steroidal, Antirheumatic Agents, Arthritis, Rheumatoid, Anti-Inflammatory Agents
    Date Created: 1998
  7. Spatio-temporal modelling using B-spline for disease mapping: analysis of childhood cancer trends [Download]

    Title: Spatio-temporal modelling using B-spline for disease mapping: analysis of childhood cancer trends
    Creator: Torabi, Mahmoud
    Description: To analyze childhood cancer diagnoses in the province of Alberta, Canada during 1983-2004, we construct a generalized linear mixed model for the analysis of geographic and temporal variability of cancer rates. In this model, spatially correlated random e®ects and temporal components are adopted. The interaction between space and time is also accommodated. Spatio-temporal models that use conditional autoregressive smoothing across the spatial di- mension and B-spline over the temporal dimension are considered. We study the patterns of incidence rates over time and identify areas with consistently high rate estimates as areas for further investigation. We apply the method of penalized quasi-likelihood to estimate the model parameters. We illustrate this approach using a yearly data set of childhood cancer diagnoses in the province of Alberta, Canada during 1983-2004.
    Subjects: geographic epidemiology, conditional autoregressive, penalized quasi-likelihood, disease mapping, generalized linear mixed model
    Date Created: 2011
  8. Complementary and Alternative Research and Education (CARE)

    Title: Complementary and Alternative Research and Education (CARE)
    Creator: ERA Administrator
    Description: Complementary and Alternative Research and Education (CARE), launched in 2003 at the Department of Pediatrics at the University of Alberta, is Canada’s first academic pediatric integrative medicine program. Its mission is to generate and disseminate evidence about pediatric complementary and alternative medicine (CAM), to ensure safe and informed use. A clinical assessment program was added in 2006.
    Subjects:
  9. Neonatology

    Title: Neonatology
    Creator: ERA Administrator
    Subjects:
  10. A spatial scan statistic for compound Poisson data [Download]

    Title: A spatial scan statistic for compound Poisson data
    Creator: Rosychuk, Rhonda J.
    Description: The topic of spatial cluster detection gained attention in statistics during the late 1980s and early 1990s. Effort has been devoted to the development of methods for detecting spatial clustering of cases and events in the biological sciences, astronomy and epidemiology. More recently, research has examined detecting clusters of correlated count data associated with health conditions of individuals. Such a method allows researchers to examine spatial relationships of disease-related events rather than just incident or prevalent cases. We introduce a spatial scan test that identifies clusters of events in a study region. Because an individual case may have multiple (repeated) events, we base the test on a compound Poisson model.We illustrate our method for cluster detection on emergency department visits, where individuals may make multiple disease-related visits.
    Subjects: spatial scan, compound Poisson, cluster detection, surveillance
    Date Created: 2013