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Spring 2014
With matrix metalloproteinases-2 (MMP2) deficiency, we observed thoracic aortic aneurysm in 70% of MMP2-/- mice but no abdominal aortic aneurysm following four weeks of angiotensin II (Ang II) infusion. We found markedly suppressed recoil properties in the thoracic aorta of MMP2-/-- Ang II mice....
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Role of Disintegrin and Metalloproteinase 17 (ADAM17) in Hypertension and Thoracic Aortic Aneurysm
DownloadFall 2018
Hypertension is a major risk factor for cardiovascular complications such as stroke, myocardial infarction, heart failure, and renal failure, and therefore is an enormous healthcare burden worldwide. The renin-angiotensin system (RAS) is an essential regulator of blood pressure homeostasis, and...
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Spring 2023
Atherosclerosis and aortic aneurysms are two major vascular diseases, and extracellular matrix (ECM) plays an important role in both as a non-cellular component of the aortic wall that also regulates vascular cell behavior and function. Atherosclerosis is a major contributor to cardiovascular...