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- 1Acute lymphoblastic leukemia
- 1Anthracyclines--Synthesis--Genetic aspects
- 1Cancer in children--Genetic aspects--Case studies
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- 1Cancer--Genetic aspects--Case studies
Results for "supervisors_tesim:"Yasui, Yutaka (School of Public Health)""
This thesis aimed to investigate congestive heart failure (CHF) associated with anthracycline exposures among the childhood cancer survivors, trying to identify differential anthracycline effects by genotype of certain genes. We had 130 childhood cancer survivors who developed CHF as cases and...
From G551D to F508del: An Inquiry Into The Development Of Targeted Therapeutics For The Treatment Of Cystic FibrosisDownload
Cystic Fibrosis (CF) is a fatal inherited disease caused by mutations in the gene encoding the Cystic Fibrosis Transmembrane Regulator (CFTR) protein. CFTR plays an integral role in salt and water transport across the epithelial membrane of major organs, such as the lungs. CFTR-targeted...
Looking beyond the standard genome-wide association study: Biologically-motivated methodological approaches to discover novel genetic variants associated with complex human traits and diseaseDownload
The standard approach for testing associations between common single nucleotide genetic variants (referred to as single nucleotide polymorphisms or SNPs) and disease entails testing disease associations for each SNP in the genome individually. This “hypothesis-free” approach has identified...
Cumulative Total Incidence for Estimating the Burden of Recurrent Events and Risk vs. Rate Concepts and Regression Models in EpidemiologyDownload
In the first part of this thesis, a straightforward intuitive method for descriptive survival analysis, termed “cumulative total incidence”, is proposed to measure the total burden of recurrent events in a population by a given time. Using data from the Childhood Cancer Survivor Study,...
Advance in biotechnologies has enabled genome-wide association studies (GWAS) that scan the entire human genome for understanding genetic contributions to the risk of a certain disease as well as to variation in treatment efficacy and side effects. In GWAS, the association between each...
Inequalities by Race/Ethnicity and Socioeconomic Position in the Incidence and Survival of Childhood Acute Lymphoblastic Leukemia in the United StatesDownload
Background: Childhood acute lymphoblastic leukemia (ALL) is the most common childhood cancer in the United States. The incidence and survival of childhood ALL have been reported to be closely associated with race/ethnicity and socioeconomic position (SEP). However, the relationship between SEP...
Identification of Shared and Distinct Gene-disease Associations Among Multiple Related Diseases and Multiple Subtypes of a DiseaseDownload
Genome-wide association study (GWAS) is an approach with high-throughput genotyping to uncover genetic susceptibilities of complex diseases. However, the genetic susceptibilities discovered usually carry very small risk increments. Additionally, the current approach to assess whether these...
As medical care in developed countries has become increasingly specialized, health care resources by necessity have become more regionalized. The assessment and management of critical illness and injury in infants and children require specialized training and experience. To improve patient care...