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Skip to Search Results- 1Alotaibi,Dhaifallah S
- 1Alzahrani, Khadija
- 1Fiteih, Yahya Muhammad
- 1Gandhi, Vivek D
- 1MacLean, Emily Iris
- 1Miciak, Gerald B
Results for "supervisors_tesim:"Vliagoftis, Harissios (Medicine)""
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Lipopolysaccharide Inhibits Interleukin–13-induced Chemokine (C-C motif) Ligand 26 in Human Airway Epithelial Cells: Possible Role in Eosinophil Chemotaxis in Allergic Asthma
DownloadFall 2017
Background Allergic asthma is characterized by increased level of Interleukin-13 (IL-13) in the lungs. IL-13 promotes eosinophilic infiltration in the airways by stimulating airway epithelial cells to release eotaxin-3 (CCL26) through the Janus activated kinase-2 (JAK-2)/signal transducer and...
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German Cockroach Extract Proteolytic Activity Down-regulates Interleukin-13 Dependent Eotaxin-3 (CCL26) Expression in Airway Epithelial Cells
DownloadFall 2018
Introduction:Allergy to inhaled allergens is an important factor to develop airway inflammation. The airway epithelium is the main barrier between the host and inhaled allergens, and its activation by allergens is a key step towards the activation of innate and adaptive immunity. German cockroach...
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Fall 2018
Proteinase-activated receptor-2 (PAR-2), a pro-inflammatory G-coupled receptor, is activated by exogenous or endogenous serine proteinases. PAR-2 is involved in the pathogenesis of inflammatory diseases including asthma. PAR-2 activation on airway epithelial cells (AECs) results in the release of...
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Spring 2022
Allergens possessing serine proteinase activity like house dust mite (HDM) and cockroach can activate proteinase-activated receptor-2 (PAR-2), a pro-inflammatory G-coupled receptor. Par-2 -/- mice develop attenuated airway inflammation compared to WT mice. PAR-2 blockage in the airways abrogated...
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A Retrospective Analysis of the Safety and Efficacy of a 6-Week Pulmonary Rehabilitation Program in Patients with Severe Pulmonary Arterial Hypertension
DownloadSpring 2014
Pulmonary Arterial Hypertension (PAH) is progressive disease characterized by reduced exercise capacity and decreased quality of life. Despite the availability of disease targeted therapies outcomes remain sub-optimal. Pulmonary Rehabilitation has proven to improve outcomes in other chronic...
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Mast Cell Response to Influenza A Infection and Their Antiviral Activity in Co-culture with Epithelial Cells
DownloadFall 2018
Well known their role in allergic inflammation, mast cells (MC) are also important in innate immunity against pathogens. MC are abundant in the respiratory tract and in close proximity to epithelial cells (EC) where they could be important in host defenses or the pathogenesis of viral infections...
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Molecular regulation and endogenous expression of CRTh2 in in vitro differentiated CRTh2+ Th2 cells
DownloadFall 2011
Allergic inflammation is mediated by T helper 2 (Th2) cells. Chemoattractant receptor homologous molecule expressed on Th2 cells (CRTh2) is expressed by Th2 cells and mediates chemotaxis and production of the Th2 cytokines interleukin (IL)-4, IL-5 and IL-13. To understand the molecular...