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- 1Apoptotic Stimulating Proteins of p53
- 1Disruption of iASPP to PP-1cα
- 1Drug development
Results for "supervisors_tesim:"Holmes, Charles (Biochemistry)""
Study of calcineurin interaction with inhibitor-1 and natural products. Towards novel calcineurin inhibitorsDownload
Calcineurin (CaN) is an eukaryotic Ser/Thr protein phosphatase that plays an important role in lymphocyte activation. Inhibition of CaN leads to immune system suppression, a necessary procedure in organ transplantation. However, use of CaN inhibitors results in toxic side effects. The search for...
Protein Phosphatase-1 (PP-1c) is a broad specificity Ser/Thr phosphatase catalytic subunit responsible for a variety protein dephosphorylation events in eukaryotic cells. The specificity and activity of PP-1c is largely controlled by over 200 regulatory subunits, including the Apoptotic...
The Apoptotic Stimulating Proteins of p53 (ASPPs) are key regulators of the human tumour suppressor transcription factor, p53. These regulators either activate (ASPP1 and ASPP2) or inhibit (iASPP) p53’s function in response to DNA damage. iASPP is overexpressed and attributed to poor survival in...