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- 1Abukhashim, Mohamed
- 1Alma'ayah, Zaid H
- 1Alshamsan, Aws
- 1Althurwi, Hassan N
- 1Asiri, Abdulrahman Y
- 1Elkhatali, Samya
Results for "supervisors_tesim:"El-Kadi, Ayman (Faculty of Pharmacy and Pharmaceutical Sciences)""
Several studies have examined the toxic effects of individual aryl hydrocarbon receptor (AhR) ligands, yet there are relatively few reports of the combined toxic effects of AhR ligands and other environmental co-contaminants, such as heavy metals. Chromium (Cr+6) is one of the major environmental...
The role of cytochrome P450 derived arachidonic acid metabolites against Angiotensin II-induced cardiac hypertrophy in Sprague Dawley rats and the RL-14 cell lineDownload
Several cytochrome P450 (CYP) enzymes and their arachidonic acid (AA) metabolites play essential roles in the maintenance of cardiovascular health, and their alteration gives rise to a number of cardiovascular diseases, including cardiac hypertrophy and heart failure. Recent data demonstrated...
The role of cytochrome P450 1B1 and its associated metabolites in the pathogenesis of cardiac hypertrophy and drug-induced heart failureDownload
Heart failure (HF) is one of the most widespread and lethal forms of heart disease worldwide. Most HF patients have a history of hypertension and left ventricular hypertrophy in addition to drug-induced cardiotoxicity. Mechanisms regulating cardiac hypertrophy and drug-induced HF have been the...
THE ROLE OF CYTOCHROME P450 AND THEIR ASSOCIATED ARACHIDONIC ACID METABOLITES IN THE INITIATION AND PROGRESSION OF CARDIAC HYPERTROPHYDownload
Heart failure (HF) is the leading cause of mortality and disability in adults worldwide. Cardiac hypertrophy is an independent risk factor and one of the major hallmarks of HF. Research in cardiac hypertrophy is considered as a research into the early events in the development of HF. The...
MODULATION OF ARYL HYDROCARBON RECEPTOR (AHR)-REGULATED CARCINOGEN ACTIVATING ENZYMES BY ORGANIC ARSENICALS: A POTENTIAL THERAPEUTIC TARGETDownload
Arsenic is a worldwide environmental pollutant that is associated with skin and several types of internal cancers, such as liver, lung, kidney, urinary bladder, and prostate cancers. Recent reports revealed that organic arsenic metabolites, such as trimethylarsine oxide (TMAO), dimethylarsinic...
In many tumors, persistently-active signal transducer and activator of transcription 3 (STAT3) imparts several oncogenic features such as survival, proliferation, angiogenesis, and immune escape. Therefore, STAT3 targeting in cancer and cancer-exposed dendritic cells (DCs) is important for cancer...
Role of cytochrome P450 (CYP) metabolites of arachidonic acid in the regulation of cAMP in HEK293 cellsDownload
Cytochrome P450 epoxygenases metabolize arachidonic acid to epoxyeicosatrienoic acids (EETs), which in turn are converted to dihydroxyeicosatrienoic acids (DHETs) by soluble epoxide hydrolase (sEH). EETs are known to modulate a number of vascular and renal functions but the exact signaling...
The voltage-gated KCNQ1/KCNE1 potassium ion channel plays a key role in maintaining the heart rhythm. An active channel generates the slow delayed rectifier (IKs) current in the heart. Both loss-of-function and gain-of-function mutations in KCNQ1 or KCNE1 are linked to many heart-related...