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- 1 Lansing, Marihan
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Results for "departments_tesim:"Medical Sciences-Paediatrics""
Pre and postnatal maternal distress and infant gut immunity in the Canadian Healthy Infant Longitudinal Development (CHILD) birth cohortDownload
Introduction: Secretory immunoglobulin A (sIgA) plays a critical role in gut mucosal immunity and is a marker of immune maturation in early life. Delayed IgA production is associated with increased risk of allergic diseases. Animal models of stressful events before birth and during infancy show...
Treatment of Adolescent Alcohol Misuse and Clinician Acceptance of Technology-facilitated Care in the Emergency DepartmentDownload
Screening, brief intervention, and referral to treatment (SBIRT) is the recommended approach for clinicians to use with adolescent patients with suspected alcohol-related problems. Although the emergency department (ED) is an opportune setting for early identification of alcohol misuse, SBIRT is...
Cyclic Adenosine Monophosphate (cAMP) and Fragile X Mental Retardation Protein (FMRP) Mediate Avoidance Behaviour in DrosophilaDownload
Fragile X Syndrome (FXS) is neurodevelopmental disorder caused by a trinucleotide CGG repeat expansion that leads to the methylation and transcriptional silencing of the Fragile X mental retardation 1 (fmr1) gene. This results in the loss of Fragile X mental retardation protein (FMRP), an...
Hypoxic-ischemic brain damage (HIBD) is still of major concern in the neonatal period, resulting in chronic neurological sequelae stemming from damage to the term newborn brain. Full-body and focal-head cooling within 6 hours of birth have proven neuroprotective in human newborns and various...
Alterations in Neural Connectivity following Placental Insufficiency, its Role in Neurodevelopmental Disabilities, and the Neuropreventive Effects of Broccoli Sprout Supplementation: A Potential Therapeutic InterventionDownload
Background Intrauterine growth restriction (IUGR) as a result of suboptimal in utero environments can cause perinatal brain injury and ultimately lead to neurodevelopmental disorders (NDD). In the developed world placental insufficiency (PI) is the leading cause of IUGR. This antepartum insult...
Patient-reported outcome measures for adverse events: A systematic review and COSMIN evaluation studyDownload
ABSTRACT Background: Health care requires constant improvement. Harms in health care are becoming a priority, as is incorporating the patient’s voice in both clinical research and clinical care. Patients have been found to provide a more subjective, detailed perspective of their treatment...
Duration of labour and its impact on the infant gut microbial composition in the Canadian Healthy Infant Longitudinal Development (CHILD) birth cohortDownload
Background: Balanced development of infant gut microbiota is pivotal for immune maturation and energy homeostasis, and infant gut dysbiosis is associated with increased risk of childhood atopy, allergy and excess weight gain. Shifts in abundance of gut Bacteroidetes and Firmicutes during infancy,...
Participatory research (PR) is a research approach which involves partnerships between researchers and those affected by the issues under study. These partnerships lead to the production of research that is relevant and applicable to those involved in the process. Despite the potential value of...
The endoplasmic reticulum is responsible for folding of newly synthesized proteins. Chaperone proteins, calreticulin and calnexin, with the thiol-oxidoreductase ERp57, interact with nascent proteins in a cycle of quality control to ensure proteins are folded correctly. In this study, we...
Acute Lung Injury/Acute Respiratory Distress Syndrome (ALI/ARDS) remain a major health issue because of a high mortality and morbidity rate. Despite progress in understanding the pathogenesis of ALI, there is currently no drug-based therapy promoting lung repair. A predominant pathological...