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- 1AL Omair, Omar Abdulrahman
- 1AL-AGILI, MARWA
- 1Abdelmoneim, AS
- 1Abdussalam, Ali MA
- 1Abukhashim, Mohamed
- 1Aburasayn, Hanin
- 7Cytochrome P450
- 6Monoclonal antibodies
- 5Epoxyeicosatrienoic acids
- 5Polymeric micelles
Results for "departments_tesim:"Faculty of Pharmacy and Pharmaceutical Sciences""
Identification and quantification of pathogenic bacteria has become one of the key elements in biodefense, food safety, diagnostic and drug discovery. The aim of the thesis is to investigate interactions between bacteria and peptides in order to utilize the potential of antimicrobial peptides...
Mobile technology interventions for improving medication adherence in patients with mental health disordersDownload
ABSTRACT Poor medication adherence in the mental health population leads to compromised treatment outcomes and increased health care costs. Traditional interventions for medication adherence, while effective if addressing multiple determinants of medication-taking behavior, are expensive and...
Abstract Topical formulations of diclofenac have become popular for treating various painful inflammatory conditions. Yet, not all formulations are suitable candidates for dermal delivery as the skin acts as a natural barrier that limits drug penetration. This barrier challenges the efficacy of...
There is a close relationship between inflammation and cancer. At site of inflammation, reactive oxygen species (ROS) are generated, including hydrogen peroxide (H2O2). The generation of ROS could, in turn, activate transcription factors that are involved in inflammation, cellular transformation,...
MODULATING CYTOCHROME P450-MEDIATED ARACHIDONIC ACID METABOLISM AS A POTENTIAL NEW TREATMENT MODALITY FOR CARDIAC HYPERTROPHYDownload
Arachidonic acid (AA) metabolism has long been a very appealing target for drug discovery and development efforts. Beside cyclooxygenase and lipoxygenase pathways, AA is also metabolized by the recently recognized cytochrome P450 (P450) pathway, forming several biologically-active...
Mitochondria are at the center of cardiac health and disease. These vital organelles provide most of the energy to the contractile apparatus and play a strategic role in cardiomyocyte survival during cellular stress. Cardiovascular diseases and many aging related diseases are often associated...
Preliminary validation of a computer-based approach to find new lead molecules targeting the oncogenic Forkhead box M1 transcription factorDownload
The upregulation of the forkhead box M1 (FOXM1) transcription factor is directly correlated with cancer initiation, invasion, and drug resistance. Because the overexpression of FOXM1 is considered an important factor in carcinogenesis, this protein could be a relevant drug target in cancer...
Buparvaquone Nanostructured Lipid Carrier Development: Physicochemical and In Vitro Leishmanicidal PerformancesDownload
Leishmaniases is a group of diseases caused by parasites of the genus Leishmania. The estimated number of deaths from visceral leishmaniases ranges from 20,000 to 50,000 annually. The most common treatment over the past 60 years has been pentavalent antimonials. Besides the doubtful...
The application of computer simulation to investigate drug absorption and bioavailability in disease statesDownload
Oral drug absorption relies mainly on the physicochemical drug properties and the interaction with the physiological environment of the body. These factors could be altered significantly under abnormal conditions and disease states. Identifying these changes can optimize drug therapy under these...
Osteoclasts are the sole cells responsible for bone resorption and their activity is central to the process of bone remodeling. Excessive osteoclast activity leads to increased bone resorption, predisposing individuals to bone conditions such as osteoporosis, Paget’s disease and the focal bone...