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Skip to Search Results- 2Jutras, Jean-David
- 2Yip, Eugene
- 1Abdou, Ismail
- 1Adamia, Sophia
- 1Alaee, Mahsa
- 1Anderson, Danielle L.
Results for "departments_tesim:"Department of Oncology""
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Regulation of Anti-tumor Immunity in Colorectal Cancer by Interaction of Exosome Immune Complexes with Fc gamma Receptors
DownloadSpring 2019
Targeted therapy is difficult for colorectal cancer (CRC) due to lack of conserved tumor associated antigens (TAA). Immunotherapies for CRC directed at TAA that can overcome intestinal tolerance need to be developed to improve survival of CRC patients. Exosomes are extracellular vesicles secreted...
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Spring 2020
To ensure faithful cell division, entry into mitosis must be inhibited in cells with damage or under-replicated DNA. Wee1 and Myt1 are two partially redundant kinases that inhibit mitotic entry through the phosphorylation of the Cdk1/cyclin B complex. Cdk1 is an essential mitotic kinase that...
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4-[18F]Fluoroiodobenzene and its applications in palladium-mediated Sonogashira cross coupling reactions
DownloadFall 2014
Way, Jenilee1; Wang, Monica1; Wuest, Melinda1; Bergmann, Cody1; Hamann, Ingrit1; Wuest, Frank1* 1 University of Alberta, Department of Oncology, Edmonton, Alberta, Canada The ongoing demand for novel 18F-labelled radiotracers is frequently accompanied with the need to develop novel radiolabelling
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Accurate Dosimetry for Ocular Brachytherapy: Measurement, Delivery Uncertainty, and Dose Calculation Studies
DownloadFall 2017
Ocular brachytherapy has been found to be an excellent alternative for the treatment of ocular melanomas compared to the predominantly used treatment prior to the 1980s of enucleation. Tumour control rates are generally >90%, overall survival rates are equivalent to enucleation, and ocular...
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Anti-cancer effects of n-3 long-chain polyunsaturated fatty acids (LCPUFA) on ovarian cancer growth in vitro and in vivo
DownloadFall 2019
Objectives: Many ovarian cancer (OC) patients relapse with chemo-resistant disease, necessitating improved therapeutic approaches. Recent studies have determined that long chain polyunsaturated fatty acids (LCPUFA) may affect cancer cell growth and metastatic potential; however, few studies have...
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Binding, internalization, and transgene expression of an adenoviral vector retargeted to HER3/4
DownloadFall 2013
Adenoviruses (Ads) have been well studied for use in cancer gene therapy. However, low levels of the primary receptor, coxsackie-adenovirus receptor (CAR), in tumor cells has been shown to be a factor in low transgene expression. To increase Ad infection of breast cancer cells we constructed a...
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Characterization of transport of positron emission tomography tracer 3′-deoxy-3′-fluorothymidine by nucleoside transporters
DownloadFall 2012
Positron emission tomography (PET) tracer 3′-fluoro-3′-deoxythymidine (FLT) is used for imaging tumor proliferation. Prior to this work, human equilibrative nucleoside transporter 1 (hENT1) was the only known human nucleoside transporter (hNT) capable of FLT transport. The aim of this research...
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Spring 2022
Radioisotopes of scandium have been proposed as potential candidates for radiotheranostics, the combination of targeted imaging and therapy of cancer. Radiolabelling specific targeting vectors with positron emitting radioisotopes (43Sc, 44Sc) provides a quantitative measure of the disease through...
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Development of a Targeted Adenoviral Vector Expressing HSV-TK for use in Breast Cancer Gene Therapy and Analysis through Positron Emission Tomography
DownloadFall 2012
While adenoviral (Ad) vectors are the most commonly used gene delivery vector for human gene therapy, improvements must be made to increase Ad specificity to tumors if they are to be used for cancer gene therapy. Our goal is to target adenoviral vectors to breast cancer (BrCa) cells to induce...