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Results for "departments_tesim:"Department of Physiology""
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Fall 2020
Introduction By 2030, 1/100 Canadians are predicted to be diagnosed with inflammatory bowel diseases (IBD); approximately 25% of cases are diagnosed in children. IBD include Crohn disease (CD) and ulcerative colitis (UC), and manifest with chronic gastrointestinal inflammation. Pathogenesis...
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Egg-white derived bioactive peptides improve insulin resistance and non-alcoholic fatty liver disease in mice: mechanisms of action
DownloadFall 2023
Zani, Stepheny Carneiro de Campos
Metabolic syndrome is a condition characterized by the presence of multiple co-morbidities including hypertension, dyslipidemia, obesity and hyperglycemia. More recently, non-alcoholic fatty liver disease (NAFLD) has been included in this cluster as the hepatic manifestation of the metabolic...
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Electrophysiological Properties of a Quail Neuroretina Cell Line (QNR/D): Effects of Growth Hormone?
DownloadFall 2012
The expression of retinal ganglion cell protein markers and voltage-gated ion channels in QNR/D cells was investigated using immunocytochemistry and the whole cell patch clamp technique, respectively. Additionally, since these cells express growth hormone and growth hormone receptor, the effects...
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Elucidating the origin of expiratory abdominal activity during sleep and analysis of its manifestation in conditions of an impaired inspiratory drive
DownloadSpring 2024
This dissertation explored respiratory control mechanisms during sleep, with a specific focus on the contribution of the lateral parafacial area (pFL) to the generation of abdominal recruitment. Existing theories posit the preBötzinger complex (preBötC) as the inspiratory oscillator and identify...
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Epigenetic Involvement in Heterosynaptic (Tagged) LTP Following Beta-Adrenergic Receptor Activation in the Mouse Hippocampus
DownloadSpring 2019
Synapses experience long-lasting plastic changes following neuromodulatory action in the brain. One natural modulator is noradrenaline (NA). Beta-adrenergic receptor (b-AR) activation by noradrenaline enhances memory formation and long-term potentiation (LTP), a form of synaptic plasticity...
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Fall 2012
Recent discoveries in stem cell biology have generated enthusiasm about the possibility of harnessing stem cells for organ repair and regeneration. The ability of pluri- and multipotent stem cells to differentiate along various cellular lineages has placed them at the core of research that seeks...
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Exploratory study of egg white hydrolysate mechanisms of action in insulin sensitive tissues of high fat diet-induced insulin resistant rats
DownloadSpring 2019
Background: Chronic diseases related to the metabolic syndrome, such as type 2 diabetes and hypertension lead to complications when not treated properly. Natural approaches able to tackle multiple aspects of the metabolic syndrome and cause minimal side effects are desired. Bioactive peptides are...