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Skip to Search Results- 11West, Frederick (Chemistry)
- 8Lowary, Todd (Chemistry)
- 1Bennet, Andy (SFU Chemistry)
- 1Cambpell, Robert (Chemistry)
- 1Hall, Dennis (Chemistry)
- 1Lucy, Charles (Chemistry)
- 1Ahmed Hamdy Mahmoud Elmenoufy
- 1Akuamoah Boateng, Maxwell
- 1Bonderoff, Sara A
- 1Bott, Tina Marie
- 1Byers, Brock W
- 1Dunbar, Christine R
- 2Interrupted Nazarov reaction
- 2Nazarov reaction
- 11,3-oxathiane
- 1Acetylcholine
- 1Allylic alcohol transposition
- 1Alternative Nazarov reaction
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Fall 2014
Carbohydrate–protein interactions play key roles in a range of biological processes. Noticeable advancements have been made in understanding the features associated with the recognition of pyranosides (six-membered ring sugars) by proteins. In contrast, similar detailed studies about the...
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Fall 2012
Mammalian glycoconjugates are composed exclusively of sugar in the thermodynamically favorable pyranose ring form; on the other hand, sugars in the five-membered furanose ring form are widespread in many bacteria, fungi, and protozoan pathogens. This makes the enzymes involved in furanoside...
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Fall 2020
At present, the number of cancer patients who develop resistance to conventional cancer therapeutics, such as DNA damaging chemotherapeutics, or radiotherapy, is increasing. A major reason for developing such resistance is that cancer cells have the ability to repair their DNA damage caused by...
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Developing an M3 Antagonist for Molecular Imaging of Muscarinic Acetylcholine Receptors in Breast Cancer
DownloadFall 2021
The lack of the three targeted receptors, estrogen, progesterone, and the human epidermal growth factor receptor 2, causes difficulty in treating triple negative type cancers. Most often, patients with this type of malignancy have a low chance of survival. The focus of this work will be on...
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Spring 2015
Diastereomeric piperidinium salts were prepared as substrates for the Stevens [1,2]-rearrangement of ammonium ylides, the key step in a proposed synthetic route towards lysergic acid, a valuable compound in medicinal and synthetic chemistry. Because of unexpected reactivity seen in the alkylation...
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Fall 2014
This dissertation expands the scope and understanding of the Nazarov electrocyclization and interception of the reactive cyclopentenyl cation intermediate that is formed though a 4π electrocyclization of a pentadienyl cation. An intermolecular process for interrupting the Nazarov is discussed....
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Spring 2015
Five-membered carbocycles are highly prevalent motifs in natural products and pharmaceutical drugs. Finding routes towards these moieties has been an attractive area of pursuit in synthetic organic chemistry. The Nazarov reaction is one that has been widely used to access cyclopentenone...
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Fall 2017
Glycans play essential roles in the life cycle of bacteria and often modulate interactions with their environment. Chemical synthesis provides a useful tool to access structurally well-defined bacterial glycans. These molecules can serve as probes for elucidating the biological function of these...
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Synthesis of Furanose Sugar Nucleotides from Mycobacterium tuberculosis and Campylobacter jejuni
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Five-membered ring furanose sugars, though absent in mammals, have been found in the cell walls of pathogenic bacteria such as Mycobacterium tuberculosis and Campylobacter jejuni. Because these sugars are only found in microorganisms, it has been proposed that inhibiting the enzymes these...