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An NMR-based approach to the structural and functional investigation of the Na+/H+ exchanger NHE1
DownloadFall 2013
The Na+/H+ exchanger isoform 1 (NHE1) is the predominant isoform in mammalian cells, and regulates intracellular pH and ion concentrations. NHE1 also interacts with numerous proteins and signalling pathways. Consequently, it has been found to influence cell volume, growth, differentiation, and...
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Mechanisms of Prion Disease: Initial Misfolding of the Prion Protein and Metabolomic Changes in the Brain
DownloadFall 2020
Prion diseases are neurodegenerative diseases that are caused by the misfolding and aggregation of cellular prion protein (PrPC) into the pathogenic form termed PrPSc. To contribute to a better understanding of the mechanism of prion disease, in this thesis I present my work on the structural...
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Structure and dynamics of biomolecules: probing muscle regulation, prion protein unfolding, and drug insertion into DNA by nuclear magnetic resonance spectroscopy
DownloadSpring 2011
Nuclear magnetic resonance (NMR) spectroscopy is a powerful approach to study the structure and dynamics of macromolecules in a close-to-native solution environment. In the present thesis I present my investigation of protein and nucleic acid structure and dynamics in a wide variety of biological...