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Skip to Search Results- 1Carew, Michael W
- 1Kaur, Gurnit
- 1Krys, Daniel
- 1Leier, Samantha A
- 1Litchfield, Marcus
- 1Perreault, Amanda C
- 2Arsenic
- 2Cancer
- 2Positron emission tomography (PET)
- 2arsenic
- 2multidrug resistance protein 2
- 2selenium
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4-[18F]Fluoroiodobenzene and its applications in palladium-mediated Sonogashira cross coupling reactions
DownloadFall 2014
Way, Jenilee1; Wang, Monica1; Wuest, Melinda1; Bergmann, Cody1; Hamann, Ingrit1; Wuest, Frank1* 1 University of Alberta, Department of Oncology, Edmonton, Alberta, Canada The ongoing demand for novel 18F-labelled radiotracers is frequently accompanied with the need to develop novel...
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Chemoselective bioconjugation reactions of tyrosine residues for application in PET radiochemistry
DownloadSpring 2018
Achieving chemoselectivity while maintaining bioorthogonality are among some of the major challenges in bioconjugation chemistry. Bioconjugation chemistry has important applications in PET radiochemistry. While modern bioconjugation techniques rely predominantly on lysine and cysteine residues...
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Evaluation of Hypoxia Induced Regulation of Nucleoside and Amino Acid Membrane Transporters in Breast Cancer
DownloadSpring 2020
Positron Emission Tomography (PET) utilizes radioactively tagged molecules to identify cancerous tissue. In most cases, membrane transporters control entry of these molecules into human cancer cells. Hypoxia-inducible factor (HIF)-1 is the master homeostatic regulator during hypoxia in human...
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Spring 2016
Arsenic is a proven human carcinogen and associated with a myriad of other adverse health effects. This metalloid is methylated in human liver to monomethylarsonic acid (MMAV), monomethylarsonous acid (MMAIII), dimethylarsinic acid (DMAV), and dimethylarsinous acid (DMAIII) and eliminated...
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Fall 2020
Over 200 million people worldwide are exposed to the proven human carcinogen arsenic, due to contaminated drinking water. Animal studies have shown that arsenic and the essential trace element selenium can undergo mutual detoxification through the formation of the seleno-bis(S-glutathionyl)...
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Molecular imaging of cyclooxygenase-2 (COX-2) and autotaxin (ATX) in cancer using positron emission tomography (PET)
DownloadFall 2020
Positron emission tomography (PET) relies on the use of β+-emitting radionuclide-bearing molecules congregating and decaying at a specific site of interest. Use of these molecules, called radiotracers, which target common tumor characteristics has become a pillar in the diagnosis of cancer and...
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Novel radiotracers for the molecular imaging of cyclooxygenase-2 (COX-2) using positron emission tomography (PET)
DownloadFall 2015
Cancer remains one of the most prevalent causes of death in the western world. Effective treatment of this disease relies on the ability to diagnose patients early and assess response to treatment accurately. This can be achieved by monitoring the expression of biomarkers relevant to the type...
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Targeting Phosphatidylserine for Positron Emission Tomography Imaging of Cell Death: Annexin V versus Phosphatidylserine-Binding Peptides
DownloadSpring 2016
There is currently no clinically approved, widely used molecular imaging agent for in vivo detection of cell death. Such an agent would be highly useful for early assessment of treatment efficacy in cancer patients, as well as for monitoring many other diseases in which cell death plays an...
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Fall 2022
Chronic exposure to arsenic causes lung, skin, and bladder cancer in humans. Conservative estimates suggest at least 92-220 million people worldwide are exposed to arsenic through consumption of contaminated water. Unfortunately, removal of arsenic from contaminated water sources is not...
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Spring 2014
Arsenic is a potent environmental contaminant and human carcinogen, occurring naturally in the earth’s crust and entering the food chain through leeching into the water supply. Upon entering the body, inorganic arsenic is methylated to mono- and di-methylated forms, the trivalent versions of...