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- 1Aderibigbe, Ayodeji O.
- 1Augustine, Aruna M
- 1Coccaro, Ersilia
- 1Kemp, Grant A.
- 1Lee, Brian L.
- 1Tzeng, Jennifer
The Na+/H+ exchanger isoform 1 (NHE1) is the predominant isoform in mammalian cells, and regulates intracellular pH and ion concentrations. NHE1 also interacts with numerous proteins and signalling pathways. Consequently, it has been found to influence cell volume, growth, differentiation, and...
The mammalian Na+/H+ exchanger isoform 1 (NHE1) is a ubiquitous membrane protein that exchanges one intracellular H+ for an extracellular Na+, thereby regulating cell pH and volume. NHE1 catalytic activity is mediated by a transmembrane (TM) domain with 12 transmembrane segments. We performed...
Mammalian Na+/H+ Exchanger 1 is a ubiquitously expressed membrane protein, which is dedicated to maintaining the acid-base balance in the cell. This balance is brought about by the exchange of one intracellular proton in exchange for extracellular sodium ion. NHE1 is the predominant isoform found...
Structural and Functional Analysis of Intracellular Loop 5 of the NHE1 Isoform of the Na+/H+ ExchangerDownload
The mammalian Na+/H+ exchanger isoform 1 (NHE1) is an integral membrane protein that regulates intracellular pH. It removes a single intracellular proton in exchange for one extracellular sodium ion. It has a large 500 amino acid N-terminal membrane domain that mediates transport and consists...
Sustained acidosis and phenylephrine activate the myocardial Na+/H+ exchanger through phosphorylation of Ser770 and Ser771Download
The mammalian Na+/H+ exchanger isoform 1 (NHE1) is a ubiquitously expressed membrane protein that regulates myocardial intracellular pH. Inhibition of NHE1 prevents hypertrophy and reduces ischemia-reperfusion (I/R) injury in animal models. To understand the regulation of NHE1 in the myocardium...
The mammalian Na+/H+ exchanger isoform 1 (NHE1) is a ubiquitous plasma membrane protein that regulates intracellular pH by removing a proton in exchange for extracellular sodium. NHE1 is expressed in many tissues including the kidney where it has been demonstrated to play essential roles in pH...
Sodium proton exchangers (NHEs) are polytopic membrane proteins that, in archaea, bacteria, yeast and plants, provide increased salt tolerance by removing excess toxic sodium, and in mammals regulate cell volume, growth, differentiation, proliferation, migration and apoptosis in relation to...