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Fall 2018

Elliott, Cameron Alistair

Magnetic resonance imaging (MRI) is a universally-used tool in clinical neurosurgery. It has revolutionized preoperative diagnosis, surgical planning, intraoperative targeting, and postoperative surveillance. Nevertheless, the idea that early, quantifiable perioperative structural changes of the

brain relate meaningfully to the prediction of long-term structural consequences and functional outcomes remains underdeveloped. The central hypothesis of this thesis is that the perioperative period provides a unique opportunity to examine brain structure using MRI, which may predict eventual clinical

structural brain damage and functional outcome; (2) the relationship between structural characteristics of various components of the limbic system, measured using perioperative MRI, and seizure control or neuropsychological outcomes in patients with drug-resistant temporal lobe epilepsy (TLE); and (3) the

Fall 2013

Zaini, Wan Hazlin

Hazlin Zaini, Zhang Chen, Min Liu, Fabrizio Giuliani, Chris Hanstock, Christian Beaulieu. Altered white matter connectivity between early Relapsing-Remitting Multiple Sclerosis patients, Abstract # 3610. Proceedings of the International Society for Magnetic Resonance in Medicine, 21st Annual...

Fall 2021

Pietrasik, Wojciech

factor analysis. To characterize the effects of age on DTI parameters more precisely, and measure their non-linear trajectories, higher order polynomial regression modeling was utilized, while structural equation modeling was used to test for mediation effects. We found that WM within all prefrontal

Fall 2013

Liu, Min

lesion, widespread gray matter (GM) and white matter (WM) abnormalities have been observed in patients. These reports suggest that TLE is a network disorder. IGE is characterized by bilateral epileptic discharges prominently in the frontal lobe. Magnetic resonance images (MRI) of patients suffering from

IGE with generalized tonic-clonic seizures only, were demonstrated to have distinct patterns of GM and WM abnormalities, indicating that those subsyndromes of IGE are the result of different underlying disease mechanisms. Overall, quantitative DTI has revealed structural brain differences in epilepsy

Fall 2022

Castro Gomez, Maria Jose

. Understanding the structural connectivity that underpins these neurocognitive deficits is crucial for furthering our understanding of PAE. This thesis aims to examine the relationships between frontoparietal and temporal white matter as assessed by diffusion tensor imaging (DTI) tractography, neurocognitive

), bilateral cingulum, inferior longitudinal fasciculus (ILF), and superior longitudinal fasciculus (SLF). All participants completed three language subtests from the NEPSY-II. Executive functioning was measured using the Behavior Rating Inventory of Executive Functioning-Parental Report (BRIEF-PR), and verbal

Fall 2010

Lebel, Catherine

Structural brain changes occur in a complex manner throughout life, and understanding healthy brain development is crucial for the study of brain abnormalities in various conditions. Diffusion tensor imaging (DTI) is an advanced magnetic resonance imaging technique that provides information about

adolescence, reached a developmental peak during adulthood, and then, during senescence, underwent a reversal of structural changes that occurred more gradually than the initial development. The genu and splenium of the corpus callosum had the earliest development, while frontal-temporal connections and the

compared to healthy controls, suggesting extensive structural brain damage. Finally, significant relationships between cognitive abilities and brain structure were observed in both populations. Brain lateralization of a frontal-temporal pathway correlated with two specific cognitive abilities in typically