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- 1Burkat, Michael
- 1Campbell, Stephen J.
- 1Hodge, Curtis D
- 1Islam, Md Touhidul
- 1Lee, Megan Sae Bom
- 1Leung, Charles
- 3F plasmid
- 2DNA Damage Response
- 2X-ray crystallography
- 1Apoptotic Stimulating Proteins of p53
Results for "supervisors_tesim:"Glover, Mark""
The conjugative transfer of bacterial F plasmids relies on TraM, a plasmid-encoded protein that recognizes multiple DNA sites to recruit the plasmid to the conjugative pore. In spite of the high degree of amino acid sequence conservation between TraM proteins, many of these proteins have markedly...
SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily A-like 1 (SMARCAL1) is a SWI2/SNF2 chromatin remodeler. It reanneals stalled replication forks to maintain genome integrity. It contains HARP domains that are necessary for the annealing activity. This thesis...
Development of Systems for Expression, Purification, and CK2-Mediated Phosphorylation of the Histone OligomersDownload
It is of extreme importance to investigate the DNA repair pathways that will lead to a better understanding to develop cancer treatments since the primary cause of cancer is the inability of the cell to restore the damaged DNA. Upon DNA damage, the histone tails of the nucleosomes near the DNA...
Multidrug resistant bacteria pose a threat to human health and economic burden for the healthcare system. Transmission of antibiotic resistance genes can occur by the conjugative transfer of the F plasmid between bacteria. The transferosome forms a channel linking the two cells together, while...
In response to genomic stress resulting from external and endogenous insults, the cell has acquired a set of complicated pathways that deal with the damage, which are collectively referred to as the DNA damage response (DDR). In order to repair double strand DNA breaks that may have occurred in...
The BRCT domain family is a group of proteins that is primarily involved in the regulation of DNA replication, cell cycle checkpoint activation, DNA damage repair, and many other DNA damage responses (DDR). Mutations in BRCT proteins often result in genomic instability, one of the leading sources...
Topoisomerase II-beta binding protein 1 (TopBP1) is a critical regulatory protein that integrates diverse signals in the DNA damage response. In response to DNA replication stress, TopBP1 participates in a series of protein interactions to collectively activate the key Ser/Thr kinase, Ataxia...
DNA is a detailed layout of instructions for cellular function. The integrity of human DNA is constantly challenged by a barrage of exogenous and endogenous sources. A regime of genome stability maintenance has evolved to repair the many different types of DNA damage. A form of communication...
Biochemical and structural characterization of CpxP and CpxA, key components of an envelope stress response in Escherichia coliDownload
The Cpx two‐component signal transduction pathway of Escherichia coli consists of an inner membrane‐localized sensor histidine kinase, CpxA, the response regulator, CpxR, and the novel periplasmic accessory protein, CpxP. These proteins mediate a bacterial stress response, sensing envelope...
The Apoptotic Stimulating Proteins of p53 (ASPPs) are key regulators of the human tumour suppressor transcription factor, p53. These regulators either activate (ASPP1 and ASPP2) or inhibit (iASPP) p53’s function in response to DNA damage. iASPP is overexpressed and attributed to poor survival in...