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Skip to Search Results- 1Burkat, Michael
- 1Campbell, Stephen J.
- 1Hodge, Curtis D
- 1Islam, Md Touhidul
- 1Kim, Hyeong Jin
- 1Kulepa, Ayodeji N
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Biochemical and structural characterization of CpxP and CpxA, key components of an envelope stress response in Escherichia coli
DownloadFall 2012
The Cpx two‐component signal transduction pathway of Escherichia coli consists of an inner membrane‐localized sensor histidine kinase, CpxA, the response regulator, CpxR, and the novel periplasmic accessory protein, CpxP. These proteins mediate a bacterial stress response, sensing envelope...
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Spring 2022
The DNA damage response (DDR) is critical for maintaining genomic integrity and prevention of genotoxic consequences leading to carcinogenesis. The DDR signaling cascade results either in the activation of the repair pathway, or initiation of apoptosis if the repair is not possible. Many...
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Investigation of the BRCT repeats in human hereditary breast cancer and DNA damage response
DownloadFall 2009
The C-terminal region of breast cancer susceptibility gene 1 (BRCA1) contains a pair of tandem BRCT repeats that are critical for the tumour suppressor function of BRCA1. BRCT repeats are present in a large of number of proteins that are implicated in the cellular response to DNA damage. A subset...
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Fall 2012
Bacterial conjugation is the process of plasmid DNA transfer from a donor cell to a recipient cell. This process is mediated in F-like plasmids by proteins expressed by the tra operon. The relaxosome forms at oriT (origin of transfer), where the nicking and unwinding of a single-stranded copy of...
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Site-directed mutagenesis of charged amino acid residues on the CpxASD and CpxP in E. coli, potentially important for signaling and direct interaction
DownloadSpring 2019
Bacterial pathogens must endure diverse environmental stresses that they encounter while colonizing and infecting a host. Two-component signal transduction systems (TCSTs) are the most widespread regulatory systems in bacteria, but importantly absent in mammals. In general, TCSTs sense and...