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- 1Abdul Rahman, Siti Aishah
- 1Acton, Leah T
- 1Aghamohammadi Sereshki, Arash
- 1Ainsley, Emily N.
- 1Bandet, Mischa V.
- 1Batty, Nicholas J.
This thesis discusses the organization of motor pathways in adults and children with cerebral palsy (CP). Individuals with CP experience impairments in the control of head and neck functions. The cranial nerves that innervate the head and neck pass through the brainstem. Thus, motor impairment...
Visually guided actions are those that are completed using available visual information, such as reaching for a cup of coffee while looking at it. In the absence of visual information, our hand actions are guided by previously stored visual information; these are known as memory-guided actions....
The major question addressed by neuroscience is how behavior can be explained through knowledge of the brain. Given the unobservable nature of mind, cognitive neuroscientists depend on observations of the electrical activity of the brain gleaned through electroencephalographic (EEG) recordings to...
The Nerve Excitability Test (NET) is an electrodiagnostic test capable of non-invasive characterization of peripheral nerves in humans. It has utility in differentiating between healthy controls and subjects with peripheral nerve disorders. Full realization of the diagnostic potential of NET...
Sex traditionally has been an understudied variable in the chronic pain literature. However, more recent research has begun to explore the role of sex in the etiology of chronic pain. The present thesis adds to the current literature by expanding on research demonstrating the significant effect...
Going Through the Motions: Evaluating the Impact of Task, Device and Platform on Mouse-Tracking Derived Measures of Decision DifficultyDownload
As decisions require actions to have an effect on the world (Cisek & Kalaska, 2010), measures derived from movements can be used to provide a powerful index of decision-making processes (e.g., Gallivan & Chapman, 2014). Measures of trajectory curvature (interpreted as a competitive pull from the...
Imaging the hemodynamics of pial collaterals and evaluating collateral therapeutics in rodent models of acute ischemic strokeDownload
Ischemic stroke is caused by blockage of a primary blood vessel supplying brain tissue. Cerebral collaterals are auxiliary vascular pathways in the cerebral circulation that can provide residual blood flow to partially maintain perfusion in ischemic tissue when primary vascular routes are...
Integrating Characteristics of Executive Functions in Non-Demented Aging: Structure, Trajectories, Classification, and Biomarker PredictorsDownload
In aging, executive function (EF) performance (level) and change (trajectory) are linked to multiple interacting risk factors. Structurally, EFs have previously been represented as either a unitary (e.g., unidimensional) or diverse (e.g., multidimensional) set of abilities that change across the...
Intermittent Electrical Stimulation as a Treatment Approach for Deep Tissue Pressure Injury after a Spinal Cord InjuryDownload
The goal of this study was to investigate the effects and mechanisms of action of an intermittent electrical stimulation (IES) paradigm on the healing of deep-seated muscle injury. Electrical stimulation has been extensively studied for the treatment of open wounds, often with amplitudes lower...
Investigating Human Brain Function and Human Brain Organization Using Functional Magnetic Resonance Imaging at 4.7 TDownload
Understanding the brain-cognition association has been a major goal of neuroscientists for more than 50 years. The discovery of functional magnetic resonance imaging (fMRI) blood-oxygen-level-dependent (BOLD) contrast by Ogawa and colleagues (1990, 1992) has fundamentally transformed the field of...