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Skip to Search Results- 2Hegadoren, Kathleen M.
- 1Adu, Medard Kofi
- 1Al-Ghamdi,Mohammad S
- 1Al-Nuaimi, Saleem K
- 1Amritraj, Asha
- 1Amusan, Precious
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The Humanization of Rodent Beta-Amyloid: The Aggregative and Toxic Properties of Amino-Terminal Beta-Amyloid Mutations
DownloadSpring 2020
Human β-amyloid1-42 (hAβ1-42) peptides are known to self-aggregate into oligomers that contribute to the degeneration of neurons and development of Alzheimer's disease (AD) pathology. Unlike humans, rodents do not develop AD, possibly due to differences in three amino acids (R5G, Y10F and H13R)...
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The interaction of phenelzine with human monoamine oxidase B: characterization and consequences
DownloadSpring 2022
Phenelzine (PLZ) is a monoamine oxidase (MAO) inhibitor developed in the 1960s which has been used clinically for psychiatric conditions such as depression and anxiety disorders. However, despite over 60 years of research, the mechanism by which PLZ exerts its effects on MAO has yet to be...
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The role of β-amyloid peptides in kainic acid-induced toxicity and its implications in Mesial Temporal Lobe Epilepsy
DownloadFall 2017
Kainic acid is a non-degradable analogue of the excitatory neurotransmitter glutamate that, when injected systemically into adult rats, can trigger seizures and progressive neuronal loss in a manner that mirrors the neuropathology of human mesial temporal lobe epilepsy (MTLE), most prevalent form...