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Skip to Search Results- 2Jutras, Jean-David
- 2Yip, Eugene
- 1Abdou, Ismail
- 1Adamia, Sophia
- 1Alaee, Mahsa
- 1Anderson, Danielle L.
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Targeting Phosphatidylserine for Positron Emission Tomography Imaging of Cell Death: Annexin V versus Phosphatidylserine-Binding Peptides
DownloadSpring 2016
There is currently no clinically approved, widely used molecular imaging agent for in vivo detection of cell death. Such an agent would be highly useful for early assessment of treatment efficacy in cancer patients, as well as for monitoring many other diseases in which cell death plays an...
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The contribution of Sting and Nlrp3 activation to anti-tumour immunity in microsatellite instable colorectal cancer
DownloadFall 2019
The constant exposure of the intestine to antigens forces the mucosal immune system to be tolerant to avoid a constitutively inflamed state. Unfortunately, immune tolerance can allow colorectal cancers (CRCs) to escape detection. The majority of CRCs are chromosomally instable (CIN) and display...
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The performance and magnetic shielding of a 6 MV in-line linac in a parallel linac-MR configuration
DownloadSpring 2012
To achieve real-time image-guided radiation therapy, the integration of a linear accelerator (linac) with a magnetic resonance (MR) imager has been proposed. This thesis presents work that investigated performance and magnetic shielding of a linac in the presence of parallel magnetic flux...
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Spring 2024
DNA double-strand breaks (DSBs) are considered the most deleterious DNA lesions. Unrepaired or incorrectly repaired DSBs can lead to cell cycle arrest, apoptosis, or over time, the accumulation of mutations and chromosomal abnormalities that give rise to cancer. The repair of DSBs by homologous...
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Fall 2017
Metastasis is the leading cause of cancer-related deaths, yet there are no therapies that directly target this process. To identify potential therapeutic targets of metastatic dissemination, we recently completed the first whole human genome shRNA screen using a novel avian embryo intravital...
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Fall 2014
Chemoresistance is one of the major hurdles to induce a cure in patients with epithelial ovarian cancer (EOC). RUNX3, belonging to the family of RUNX transcription factors, has been shown to act in an oncogenic manner by promoting proliferation and colony formation when overexpressed, in EOC....