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Skip to Search Results- 2Jutras, Jean-David
- 2Yip, Eugene
- 1Abdou, Ismail
- 1Adamia, Sophia
- 1Alaee, Mahsa
- 1Anderson, Danielle L.
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Fall 2019
Within a tumour, only a subset of cells are able to initiate neoplasms when transplanted or following localization to different organs. These tumour-initiating cells, often called cancer stem cells (CSCs) due to their high cellular plasticity, were found to exhibit particular resistance to...
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Fall 2009
Human cells possess multiple nucleoside transporters (NTs) that belong to either the human equilibrative or concentrative NT (hENT: hENT1/2/3/4; hCNT: CNT1/2/3) families. In the kidney, coupling of apical hCNT3 activities to basolateral hENT1/2 activities is hypothesized to mediate renal...
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Response of Lipid Olefinic Protons to In-Vivo Magnetic Resonance Spectroscopy Sequences at 3 T
DownloadSpring 2014
Magnetic Resonance Spectroscopy (MRS) measurements of lipid unsaturation are relevant in the study of a number of diseases. The olefinic resonance yields a measure of lipid unsaturation and is often obscured by water signal in-vivo. The objective of this work is to investigate the response of...
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Fall 2010
Patients diagnosed with malignant glioma tumours have median survivals of 1.6 yrs and 5 months, respectively, highlighting the deadly nature of this disease. Despite aggressive multimodal treatment, patients with malignant glioma often present with secondary brain tumours at sites distal to the...
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Fall 2021
DEAD Box 1 (DDX1) is a member of the DEAD box protein family of RNA helicases involved in all aspects of RNA metabolism. Although several DEAD box proteins have been well characterized, the biochemical activity of the majority of DEAD box proteins remains to be studied. DDX1 is mostly localized...
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Fall 2021
Glioblastoma (GBM) is the most common primary brain malignancy and has a dismal prognosis. Despite advanced therapies, including surgery and concurrent radiotherapy with temozolomide (TMZ), GBM patients only have a 14.6-month median survival time. This dismal outcome can be attributed to the...
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Role of human polynucleotide kinase/phosphatase (PNKP) in nuclear and mitochondrial DNA repair
DownloadFall 2015
DNA is continuously under stress from the insults inflicted by both endogenous and exogenous agents. These agents include endogenous reactive oxygen species (ROS), ionizing radiation (IR) and many common chemotherapeutic drugs, which can inflict a plethora of DNA lesions including abasic sites,...
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Fall 2018
Gene regulation pathways involved in embryonic development are commonly implicated in cancer. Transcription factors play key roles in all aspects of development including cell proliferation, migration and differentiation. Aberrant expression of many developmentally-regulated transcription factors...
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Silencing immunoglobulin gene enhancers as a potential treatment strategy for multiple myeloma
DownloadFall 2009
Multiple myeloma is a bone marrow malignancy characterized by the presence of monoclonal plasma cells. In 50-75% of myeloma patients, chromosome translocations at the IgH locus are observed, which result in overexpression of oncogenes from the translocated chromosome due to linkage with the IgH...
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Fall 2014
The purpose of this work is to understand properties of skeletal muscle of cancer patients experiencing severe muscle depletion. These studies were done using computed tomography (CT) imaging and patient information (demographics), and collection of muscle biopsies to analyze using flow...