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Besides being the most popular drug in the world, caffeine is an attractive tool used in research to help us answer fascinating scientific questions, because caffeine impinges on a number of molecular pathways. In my research, I used caffeine to study DNA repair pathways and insect xenobiotic...
High resolution optical tweezers for single molecule studies of hierarchical folding in the pbuE riboswitch aptamerDownload
Riboswitches are gene regulatory elements found in messenger RNA that function by changing structure upon the binding of a ligand to an aptamer domain. Single adenine-binding pbuE riboswitch aptamer RNAs were unfolded and refolded co-transcriptionally using optical tweezers for single molecule...
Malignant glioma (MG), comprised of grade III (anaplastic astrocytoma) and grade IV (glioblastoma) astrocytoma, is the most common adult brain tumour, with an incidence of ~4 in 100 000 people. Despite aggressive treatment with surgery, radiation, and chemotherapy, survival remains dismal, with...
This file is a Spanish transcription of Programa Nosotros Episode #11 created for Professor Ann de Leon's course Spanish 405 at the University of Alberta in the fall of 2016 as part of the community service learning portion. The television episode aired on March 21, 1993.
This file is a Spanish transcription of Programa Nosotros Episode entitled Salud or Health created for Professor Ann de Leon's course Spanish 405 at the University of Alberta in the fall of 2016 as part of the community service learning portion. The television episode aired on April 29, 1990.
In photosynthetic organisms it is becoming increasingly evident that light-driven shifts in redox potential act as a sensor that initiates alterations in gene expression at both the level of transcription and translation. This report provides evidence that the expression of a cyanobacterial RNA...
Regulation of cold shock-induced RNA helicase gene expression in the cyanobacterium Anabaena sptrain PCC 7120Download
Expression of the Anabaena sp. strain PCC 7120 RNA helicase gene crhC is induced by cold shock.crhC transcripts are not detectable at 30°C but accumulate at 20°C, and levels remain elevated for the duration of the cold stress. Light-derived metabolic capability, and not light per se, is required...
A transcription of Russell's marginal comments in his copies of Frege's works, from his readings of Frege in 1902. The greatest number are in the early sections of Grundgesetze der Arithmetik, Vol. I, but there are also marginal comments in Begriffsschrift, Grundlagen der Arithmetik, \"Ueber...
Separable whorl-specific expression and negative regulation by enhancer elements within the AGAMOUS second intronDownload
We analyzed the 4-kb intragenic control region of the AGAMOUS (AG) gene to gain insight into the mechanisms controlling its expression during early flower development. We identified three major expression patterns conferred by 19 AG::reporter gene constructs: the normal AG pattern, a...
Studies on the control of tRNA transcription by the replication stress checkpoint
RNA polymerase III (RNAPIII) pre-initiation complexes at tRNA genes naturally cause replication fork pausing in the yeast Saccharomyces cerevisiae, and interference with replication is known to have deleterious effects on genome stability. It follows that repression of tRNA gene transcription...