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A Method to Enhance Re-Endothelialization of Tissue Engineered Decellularized Allograft Heart ScaffoldsDownload
Allograft tissue is used to reconstruct cardiac birth defects but induces an immune response resulting in allo-sensitization. Decellularization reduces the immune response, however, acellular vascular tissue is thrombogenic. In-vitro endothelialization may attenuate thrombogenicity. Here we offer...
Background: Hypertrophic scar (HTS) is a fibroproliferative disorder of the skin that results in the development of painful, red, raised scar lesions. Transforming growth factor beta 1 (TGF-β1) has been implicated as a key driver of this disorder. Primarily, these effects include an increased...
The rules of governance are changing. They are necessarily becoming more stringent as interventions offered to treat conditions carry unpredictable side effects, often associated with novel therapeutic vectors. The clinical relevance of this relates to the obligations of those involved in...
This thesis was intended to develop two tissue engineering approaches for cleft palate reconstruction. One approach focused on developing a cell-based therapy in vitro, using osteogenically induced mesenchymal stem cells (MSCs). The other approach focused on the delivery of bone morphogenetic...
The development of the Edmonton protocol was an important milestone in the process of establishing islet transplantation as a cure for diabetes. However, many challenges must still be overcome, including the shortage of donor organs. To address this issue, we believe that neonatal porcine islets...