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- 2Al Sayah, Fatima
- 1Adams, Denise
- 1Cobban, Sandra J
- 1Colmers, Isabelle N.
- 1Conter, Henry J
INTRODUCTION Antioxidant micronutrients may help alleviate oxidative stress in cystic fibrosis (CF) lung disease. To determine treatment effect, systematic reviews (SR) synthesize available evidence. Cochrane SRs are known for being methodologically rigourous, however, may have...
Patient-reported outcome measures for adverse events: A systematic review and COSMIN evaluation studyDownload
ABSTRACT Background: Health care requires constant improvement. Harms in health care are becoming a priority, as is incorporating the patient’s voice in both clinical research and clinical care. Patients have been found to provide a more subjective, detailed perspective of their treatment...
This thesis presents the results of three studies examining the management of migraine in children. First we conducted a systematic review of all clinical trials conducted in children and adolescents of the acute migraine therapy. A meta-analysis of the 26 randomized controlled trials is...
Telemedicine is a promising but unproven tool for improving the quality of chronic disease care. The aim of this research is to investigate the potential of telemedicine for the care of patients with chronic diseases in Canada. We did a systematic review and meta-analysis of telemedicine for...
The Effectiveness of Cognitive Behavioural Therapy for Secondary Prevention of Coronary Heart Disease: A Meta-AnalysisDownload
The effectiveness of secondary prevention (SP) for coronary heart disease (CHD) is well established. The poor integration of evidence into clinical practice remains problematic, in part due to the poor description of trials evaluating these programs. As a result, knowledge users remain unclear...
The Experiences of Advanced Placement and International Baccalaureate Diploma Program Participants: A Systematic Review of Qualitative ResearchDownload
Enriched high school curricula like the Advanced Placement and International Baccalaureate Diploma programs are endorsed as enhanced entry programs for postsecondary-bound students. Program participation is perceived to have benefits that appeal to broad stakeholder groups of students, parents...
Background: There is emerging evidence that randomized trials are subject to biases. Flaws in the design of such trials can result in over- or underestimation of the treatment effect size. Aim: To examine the empirical evidence for bias, to quantify the extent of bias associated with methodology,...
How the costs of research and its associated risks contribute to a minimum price that would support continued private pharmaceutical investment is unclear. We employed a linear cost-volume-revenue breakeven analysis to equate initial capital investment and risk, and its associated...
The validity, reliability and time requirement of study model analysis using cone-beam computed tomography generated virtual study modelsDownload
Objectives: To investigate the validity, reliability and time spent on performing a full orthodontic study model analysis (SMA) on Cone Beam Computed Tomography (CBCT)-generated dental models (Anatomodels) compared with conventional Plaster models and a subset of Extracted Premolars. Methods:...
The increasing popularity of traditional Chinese medicine (TCM) therapies as health care options warrants thorough examination of the efficacy and safety evidence around these therapies. This thesis explores the intersection of TCM and fatigue using two rigorous methodologies: systematic reviews...