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The five-membered carbocycle is a structural motif found in a plethora of natural products and bioactive compounds. The Nazarov reaction has emerged as an effective method to synthesize cyclopentenones and acts as a tool for adding structural complexity to molecular frameworks. This dissertation...
Organic chemistry has its foundations in the 19th century; since, it has grown into a number of industries affecting our daily lives such as the manufacture of goods and life saving pharmaceuticals. The need for new and increasingly efficient synthetic methods has grown in response to the...
Seven- and Eight-Membered Ether Formation via Sulfonium Ylide Rearrangement Processes and Application in an Approach to (+)-LaurencinDownload
Given the large number of biologically active natural products containing medium-sized ether motifs, many organic chemists have shown great interest for developing new methodologies to access these structures. In particular, numerous synthetic methodologies for the construction of seven-membered...
Synthesis, structures and reactions of hydrotris(pyrazolyl)borate complexes of divalent and trivalent lanthanidesDownload
The synthesis and reactions of hydrotris(pyrazolyl)borate, (TpR,R′) supported ytterbium(II) borohydride and lanthanide(III) dialkyl (Ln = Yb, Lu) complexes were investigated. The lanthanide(III) dialkyl complexes were found to undergo both hydrogenolysis reaction and protonolysis reaction with...
Synthetic Polyprenol-Pyrophosphate Linked Oligosaccharides Are Efficient Substrates for Mycobacterial Galactan Biosynthetic EnzymesDownload
Mycobacteria, including the human pathogen Mycobacterium tuberculosis, produce a complex cell wall that is critical for their survival. The largest structural component of the cell wall, the mycolylarabinogalactanpeptidoglycan complex, has at its core a galactan domain composed of...
The pradimicins are natural products that are both structurally intriguing to a synthetic chemist and possess biological activity as antifungal and antiviral agents. Our interest towards designing a synthetic route for these compounds and various analogues was sparked by the potential to produce...
The Synthesis of and Methodology for Archipelago Model Asphaltenes with a Benzo[b]anthraquinoline CoreDownload
The efficient synthesis of model asphaltenes as polyaromatic, nitrogenous compounds is reported. These model asphaltenes are to be used for supramolecular investigation for developing enhanced bitumen processing methodology. Our synthesis of benzo[f]quinoline and benzo[b]anthraquinoline...
Fluorous phase chemistry is an emerging field in terms of new separation techniques. A highly fluorinated compound tends to dissolve in a fluorinated solvent rather than in a common organic solvent. Fluorophilic solid phase separation (F-SPE) techniques are also well established. Our goal is to...