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- 7Stem cells
- 1Bronchopulmonary Dysplasia
- 1Cancer--Immunological aspects
- 1Computer modeling
- 1Dendritic cells
- 1Aldosary, Tagreed
- 1Alsagheir, Ali I
- 1Elliott, J. A.
- 1Ladak, Adil
- 1McCall, Michael David
- 1McGann, L. E.
Differentiation of human embryonic stem cells into hepatocytes and their in vivo application for hepatitis C viral productionDownload
Abstract Introduction: Chronic hepatitis C virus (HCV) infection is a global problem. The World Health Organization estimates that about 170 million individuals around the world are infected with HCV. Chronic HCV has a high rate of morbidity and mortality due to cirrhosis and hepatocellular...
Endothelial Colony Forming Cells: Role in Bronchopulmonary Dysplasia and evaluation of new therapeutic strategiesDownload
Bronchopulmonary dysplasia (BPD), a chronic lung disease of prematurity, results in alveolar simplification and respiratory distress in the newborn. Vascular component is implicated. Lung damage involves a deficiency in the number and function of progenitor cells. We hypothesize that endothelial...
Islet transplantation is promising treatment for certain patients with type 1 diabetes who experience recurrent episodes of hypoglycemia with unawareness. One opportunity to improve on islet transplant outcomes and potentially broaden the recipient population, is to reduce the early post...
Expansion and Osteogenic Differentiation of Human Umbilical Cord Perivascular Stem Cells by Low Intensity Pulsed Ultrasound for Dentofacial Tissue EngineeringDownload
The objective of these experiments is to explore the effect of LIPUS on the ultraexpansion and osteogenic differentiation of harvested passage-4 HUCPV-SCs. HUCPV-SCs were divided into two groups: a treatment group that received LIPUS for 10 minutes for 1, 7, and 14 days and a control group that...
Investigating cryoinjury using simulations and experiments: 1. TF-1 cells during two-step freezing (rapid cooling interrupted with a hold time)Download
There is significant interest in designing a cryopreservation protocol for hematopoietic stem cells (HSC) which does not rely on dimethyl sulfoxide (Me2SO) as a cryoprotectant. Computer simulations that describe cellular osmotic responses during cooling and warming can be used to optimize the...
Peripheral nerve regeneration: A study of surgical and biological techniques to enhance functional regenerationDownload
Unlike the central nervous system, axonal regeneration does occur in the peripheral nervous system, however, despite this, functional recovery from nerve transection injury remains dismal. This has been attributed to factors intrinsic to the motor or sensory cell body and to elements in the...