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- 5Spinal cord
- 1Central pattern generator
- 1Control system
- 1DI6 interneuron population
- 1Dorsoventral patterning
- 1Electrical stimulation
This thesis examines the cellular basis of the acute (<1 hour) anti-allodynic actions of the clinically-approved neuropathic pain drug gabapentin (GBP) in rats at the level of the spinal dorsal horn and primary somatosensory cortex. Although the clinical effectiveness of the alpha-2-delta (α2δ)...
Connectivity and Regional Distribution of Constituent Cells of the Mammalian Locomotor Central Pattern GeneratorDownload
The mammalian spinal cord contains a network of neurons capable of generating the rhythm and coordinating the complex motor pattern which underlies overground locomotion. This network, called the locomotor central pattern generator (CPG), can operate in isolation from afferent input and...
Multi-electrode arrays are essential tools to interface with the nervous system. The development of a flexible-based electrode array used to interface with the spinal cord is reported. A 2D finite element model (FEM) was developed to characterize the design parameters of such an array. A...
Walking is a locomotor task that integrates information from all over the nervous system. The lumbosacral spinal cord houses neural networks that contribute to locomotion. These networks dominate locomotor activity during development and may provide suitable targets for restoring function after...
Development of the vertebrate central nervous system is a complex process that relies on the accurate spatiotemporal distribution of signaling centers during embryogenesis. These signals provide cells with positional information, which is integrated via transcription factors and gene regulatory...