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Fall 2017
Prion disease, or transmissible spongiform encephalopathy (TSE), is a type of neurodegenerative disease for which there is no treatment and which is invariably fatal. Prion diseases are distinct in the field of biology and medicine, not only because they can be sporadic, infectious, or inherited,...
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Fall 2012
Provided that infectious prions (PrPTSE) are inactivated, composting of specified risk material (SRM) may be a viable alternative to rendering and land filling. The overall objective of this research was to utilize laboratory-scale composters to assess the degradation of SRM and PrPTSE during...
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Identification of Signaling Pathways Dysregulated during Scrapie Pathogenesis using a Kinomics Approach
DownloadSpring 2017
Prion diseases are a family of chronic lethal neurodegenerative diseases that affect humans and animals. The conversion of the cellular prion protein (PrPC) to abnormal conformations (PrPSc) is accepted to be required for pathogenesis. However, the molecular mechanisms whereby PrP conversion...