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Does IGFR1 inhibition result in increased muscle mass loss in patients undergoing treatment for pancreatic cancer?Download
BackgroundIGF-1 plays a role in the growth of multiple tumor types, including pancreatic cancer. IGF-1 also serves as a growth factor for muscle. The impact of therapeutic targeting of IGF-1 on muscle mass is unknown.MethodsWe evaluated muscle mass at L3 in patients enrolled in a randomized phase...
Elevated Fatty Acid Content in Muscle is Prevented by EPA and DHA in an Animal Model of Colorectal Cancer Receiving CPT-11 / 5-FUDownload
This study aimed to assess the effect of irinotecan / 5-fluorouracil treatment on amount and types of fatty acids in skeletal muscles of tumor-bearing rats fed: a) control diet, b) fish oil diet. Rats bearing the Ward colorectal carcinoma were fed a semi-purified diet with or without fish oil...
Methods for body composition analysis in obese adults/Métodos de análise da composição corporal em obesosDownload
The analysis of body composition in obese individuals has been intensively discussed due to the methodological limitations of most measurement methods. The aim of this thematic section was to clarify the characteristics, advantages, and limitations of methods of body composition evaluation in...
Osteopenia/osteoporosis, sarcopenia, and obesity are commonly observed in the process of aging, and recent evidence suggests a potential interconnection of these syndromes with common pathophysiology. The term osteosarcopenic obesity has been coined to describe the concurrent appearance of...
Adults with class II/III obesity (BMI ≥35 kg/m2) are at increased health risk, and may also present with lower lean mass in relation to excess adiposity, a condition termed sarcopenic obesity. A variety of body composition indices and cutpoints have been used to define this condition, mostly in...
Sarcopenia is associated with clinical outcomes and physical function in children with end-stage liver disease pre-and-post liver transplantationDownload
Background & Aims: Sarcopenia is defined as reduced skeletal muscle mass (myopenia), muscle strength and physical performance. In adults with end stage liver disease (ESLD), sarcopenia is highly prevalent and associated with adverse outcomes. Emerging data have shown that sarcopenia is prevalent...