Search
Skip to Search Results- 1Charrunchon, Sookpichaya
- 1Halma, Matthew
- 1Healey, Mark A
- 1Lu, Patricia.
- 1Ritchie, Dustin B.
- 1Sand, Rheanna M.
-
Spring 2012
Voltage-gated potassium (Kv) channels regulate the flow of potassium ions across the cell membrane of nerves and muscles. Proper functioning of these and other voltage-gated ion channels is critical for an animal to sense the environment and respond quickly to stimuli. Dysfunctional Kv channels,...
-
Fall 2016
α-Synuclein has been implicated in the progression of Parkinson’s disease, a neurodegenerative disorder that affects millions of people worldwide. This work reports on the structural propensity and druggability of this protein using a combination of Monte Carlo, Molecular Dynamics, and Virtual...
-
Force spectroscopy of the frameshift signal from West Nile virus reveals multiple folding pathways and structural heterogeneity
DownloadSpring 2019
Programmed ribosomal frameshifting (PRF) represents an important mechanism for translational genetic recoding, especially in viruses. The components of a PRF stimulator have been well characterized, though accounting for the variation in the frameshift stimulating efficiency has thus far been...
-
Fall 2013
Protein folding involves a stochastic search through the configurational energy landscape towards the native structure. Although most proteins have evolved to fold efficiently into a unique native structure, misfolding (the formation of non-native structures) occurs frequently in vivo causing a...
-
Spring 2010
More than 90% of human genes undergo a processing step called splicing, whereby non-coding introns are removed from initial transcripts and coding exons are ligated together to yield mature messenger RNA. Roughly 50% of human genetic diseases correspond to aberrant splicing. Splicing is...
-
Fall 2017
The formation of an abnormal form of proteins in cells can cause aggregation and neurodegenerative pathology, such as Alzheimer’s, Parkinson’s and prion diseases, which affects both humans and animals. Nowadays, the understanding of the mechanism of prion misfolding and propagation, including...