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Spring 2010
Inflammatory bowel disease (IBD) such as Crohn’s disease (CD) and ulcerative colitis (UC) are chronic intestinal diseases characterized by inflammation of the gastrointestinal area resulting in abdominal pain, chronic diarrhoea, and weight loss. IBD affects 1 in 1000 individuals and between 10%...
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Molecular and Epigenetic Insights into RASSF1A Regulated Pathways in Inflammatory Bowel Disease
DownloadFall 2018
Inflammatory Bowel Disease (IBD) is an idiopathic non-curable disease characterized by pain, chronic diarrhea, rectal bleeding with weight loss and erosion of the colon in severe cases. In many cases, IBD is a chronic relapsing inflammatory disorder of the gastrointestinal tract that usually...
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Fall 2011
Ras association domain family 1 A (RASSF1A) is an important tumor suppressor, which expression is frequently lost in various cancers due to promoter hypermethylation. Chronic inflammation, such as inflammatory bowel disease (IBD), can increase the risk of developing cancer. Rassf1a conventional...
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Spring 2015
The tumor suppressor protein Ras association domain family 1A (RASSF1A) has roles in multiple signaling pathways including modulating apoptosis, the cell cycle, DNA damage, and microtubule organization. RASSF1A has been shown to be one of the most frequently epigenetically silenced genes in a...
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Spring 2018
Inflammatory bowel disease (IBD) is a chronic relapsing and remitting disease of the gastrointestinal tract. There are several risk factors involved in IBD pathogenesis which are environmental, microbial and genetic factors. More than 200 susceptible genes are linked to IBD and many are involved...