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- 3Chronic wasting disease
- 2Protein misfolding cyclic amplification
- 1Aguzzi, Adriano
- 1Baral, Pravas K.
- 1Braithwaite, Shannon Lynn
- 1Ding, Ning
- 1Duque Velasquez, Juan C
- 1Forbes, Keldi
Antemortem identification of Creutzfeldt-Jakob disease (CJD) patients is initially based upon clinical presentation of the disease. Symptoms are assessed in combination with results from cerebrospinal fluid (CSF) analysis, electroencephalography (EEG), magnetic resonance imaging (MRI), and...
Prion disease, or transmissible spongiform encephalopathy (TSE), is a type of neurodegenerative disease for which there is no treatment and which is invariably fatal. Prion diseases are distinct in the field of biology and medicine, not only because they can be sporadic, infectious, or inherited,...
Chronic wasting disease (CWD) is a contagious prion disease spreading and emerging in wild and captive Cervidae species worldwide. Prion diseases are fatal neurodegenerative disorders occurring in various mammalian species including deer, elk, sheep, cattle and humans. Central to prion...
Characterizing patterns of tissue tropism and environmental reservoirs of PrPCWD in infected cervidsDownload
Chronic wasting disease (CWD) is a fatal prion disease affecting cervids. Believed to be transmitted horizontally, the factors affecting CWD contagion are unknown, but bodily fluids or excretions have been implicated as possible routes of transmission. Protein misfolding cyclic amplification...
Provided that infectious prions (PrPTSE) are inactivated, composting of specified risk material (SRM) may be a viable alternative to rendering and land filling. The overall objective of this research was to utilize laboratory-scale composters to assess the degradation of SRM and PrPTSE during...
Crystallization and preliminary X-ray diffraction analysis of prion protein bound to the Fab fragment of the POM1 antibodyDownload
Prion diseases are neurodegenerative diseases that are characterized by the conversion of the cellular prion protein PrPc to the pathogenic isoform PrPsc. Several antibodies are known to interact with the cellular prion protein and to inhibit this transition. An antibody Fab fragment, Fab POM1,...
Evaluating the Role of Bacterial Lipopolysaccharide on Etiology and Pathogenesis of Transmissible Spongiform EncephalopathiesDownload
Transmissible spongiform encephalopathies (TSEs) or otherwise known as prion diseases are a class of fatal neurodegenerative diseases related to irreversible brain damage. Presently, there is no effective treatment or preventive strategy for this disease because the etiology and biological...
Misfolded prions (PrPSc) are well known for their resistance to conventional decontamination processes. The potential risk of contamination of the water environment, as a result of the disposal of specified risk materials (SRM), has raised public concerns. Ozone is commonly utilized in the water...
Investigation on the uptake of functional proteins and infectious prions into wheat plants through the root systemDownload
Prions are the proteinaceous particle responsible for infections in a class of neurodegenerative diseases. These diseases affect a number of mammals including cervids where it is termed Chronic Wasting Disease (CWD). Prions enter the environment and persist for years. Plants have the ability to...
New Aspects of Nazarov Reaction: Additive Effects, Gold Catalysis and Application Toward the Synthesis of TaxinineDownload
Methods involving efficient and stereoselective carbon-carbon bond formation enable chemists to synthesize bioactive natural products and drugs. The Nazarov reaction is a versatile tool for the construction of functionalized cyclopentenones. This 4π-electrocyclization provides easy and efficient...