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Development of a Targeted Adenoviral Vector Expressing HSV-TK for use in Breast Cancer Gene Therapy and Analysis through Positron Emission TomographyDownload
While adenoviral (Ad) vectors are the most commonly used gene delivery vector for human gene therapy, improvements must be made to increase Ad specificity to tumors if they are to be used for cancer gene therapy. Our goal is to target adenoviral vectors to breast cancer (BrCa) cells to induce...
Exploiting the Enhanced Permeability and Retention Effect for the Targeting of Tumors with 18F-SiFA Polymer NanoparticlesDownload
Over the last several decades great progress has been made in cancer diagnosis and detection. One foundation of this progress has been improved imaging technologies. Among the most promising imaging technologies for cancer detection is Positron Emission Tomography (PET). PET imaging allows for...
Radiosynthesis and Optimization of 18F-Fluorinated GW2580 Derivatives as A Dual Trk/CSF-1R Radiotracer for Potential Use in PET ImagingDownload
As one of the medical imaging modalities applied in clinical diagnosis of various diseases, positron emission tomography (PET) is used to non-invasively visualize cellular and molecular changes that are occurring in the human body. Fluorine-18 [18F] is the most widely used radionuclide for...
Tracer Development for the Molecular Imaging of Breast Cancer: Synthesis and Biological Evaluation of C-3 Modified 2,5-Anhydro-D-mannitol Derivatives as Potential Tracer MoleculesDownload
Mammography is the most frequently used imaging method for the detection of breast cancer. Despite the key role of mammography in the breast cancer detection, false-negative diagnosis by mammograms ranges from 4 to 34%. Positron emission tomography (PET), a tracer based molecular imaging method...