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- 12Next-generation sequencing
- 2Canada, Alberta, Fort McMurray
- 8Graduate Studies and Research, Faculty of
- 8Graduate Studies and Research, Faculty of/Theses and Dissertations
- 2Oil Sands Research and Information Network (OSRIN)
- 2Oil Sands Research and Information Network (OSRIN)/OSRIN Technical Reports
- 1Biological Sciences, Department of
- 1Biological Sciences, Department of/Journal Articles (Biological Sciences)
Application of Next Generation Sequencing and Bioinformatic Approaches to the Study of Influenza Virus Strains and MiRNA Profiling in Liver DiseasesDownload
Analysis and interpretation of next generation sequencing data has posed a significant challenge to researchers, especially to those who are not equipped with expertise in bioinformatics. In this thesis, I investigated three different biomedical questions using NGS and bioinformatic approaches,...
Characterization of Norovirus strains and a seroprevalence study to understand the fluctuation of outbreak activity in Alberta, CanadaDownload
Norovirus (NoV) is recognized as the leading agent causing gastroenteritis among individuals of all ages. Historical data of NoV outbreak surveillance in Alberta, Canada, from the period July 2000 to June 2008 demonstrated a biennial pattern of NoV outbreak activity, in which peaks of high...
Combined Assembly of Metagenomic Libraries from The Faecal Samples of IBD and PSC Patients Allowed The Identification of African Swine Fever Virus-like SequencesDownload
Metagenomics is an emerging discipline to explore microbial diversity in clinical samples, independent of the limitations of cell cultures. This method is widely accepted as a modern technique to detect novel viruses in clinical and environmental samples and has the potential to contribute to the...
Next Generation Sequencing of Protists as a Measure of Microbial Community in Oil Sands Tailings Ponds: Amplicon Versus Metagenomic ApproachesDownload
The Alberta oil sands provide a major benefit to the province as an economic driver. At the same time, their responsible exploitation, particularly in mitigating the environmental impact of oil extraction stands as a significant challenge to be addressed. One of the most contentious aspects is...
Next-Generation Sequencing of Protists as a Measure of Natural Soil Microbial Eukaryotic Community in the Oil Sands RegionDownload
Soil plays a central role in the functioning of all terrestrial ecosystems. Among the many ecosystem services to which soil contributes are: purification and storage of water, sequestration of organic matter, nutrient cycling for plant growth, and conservation of healthy faunal and microbial...
Cancer cachexia (CC) is a multifactorial syndrome characterized by severe depletion of skeletal muscle, with or without fat loss. A majority of cancer patients with incurable cancer are affected with cachexia and it remains an unmet medical need. Gene expression changes at the transcriptional...
Breast cancer (BC) continues to be one of the leading causes of cancer related death among women. Despite continuous progress in screening, diagnosis and treatment of BC, a subset of patients experience recurrence and/or death. Optimal management of BC has remained a challenge due to these...
STRESS RESPONSES OF THE FLAX GENOME: ACTIVATION OF TRANSPOSABLE ELEMENTS, DEFENSE GENES AND GENOME RESTRUCTURING AND DIVERSIFICATION.Download
Transposable elements (TEs) are DNA sequences that can move in the genome (transpose) via a DNA or a RNA intermediate. TEs are abundant in plant genomes and can be activated by stress. Their activity can result in structural and gene expression alterations that increase diversity within and among...
Single-nucleotide polymorphism discovery in Leptographium longiclavatum, a mountain pine beetle-associated symbiotic fungus, using whole-genome resequencingDownload
Single-nucleotide polymorphisms (SNPs) are rapidly becoming the standard markers in population genomics studies; however, their use in nonmodel organisms is limited due to the lack of cost-effective approaches to uncover genome-wide variation, and the large number of individuals needed in the...