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Spring 2011
The goal of this thesis is to investigate the biophysical basis underlying the nonlinear relationship between firing response and current stimulation in single motor neurons. After reviewing the relevant motoneuron physiology and theories that describe complex dendritic signaling properties, I...
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Calcium Imaging and Field Potential Analysis of Autocrine Neuromodulation in the Locus Coeruleus of Newborn Rat Brain Slices
DownloadFall 2022
The locus coeruleus (LC) is a small brainstem nucleus that controls diverse behaviours and brain functions via release of noradrenaline (NA) in the neonatal time period. There is increasing evidence of complexity in this neuron-astrocyte ‘neural’ network that remains mostly unexplored in...
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Evaluating the Role of Bacterial Lipopolysaccharide on Etiology and Pathogenesis of Transmissible Spongiform Encephalopathies
DownloadFall 2014
Transmissible spongiform encephalopathies (TSEs) or otherwise known as prion diseases are a class of fatal neurodegenerative diseases related to irreversible brain damage. Presently, there is no effective treatment or preventive strategy for this disease because the etiology and biological...
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The roles of Pbx and Meis TALE-class homeodomain transcription factors in vertebrate neural patterning
DownloadFall 2010
One of the major goals of developmental biology is to understand how specialized groups of cells arise from an initially unspecified cell population. The vertebrate hindbrain is transiently segmented along its anterior-posterior axis into lineage-restricted compartments called rhombomeres, making...