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- 1Ayoub, Ahmed T
- 1Bajaj, Megha
- 1Brockley, Graham Hardcastle.
- 1Churchill, Cassandra D.M.
- 1Friesen, Douglas E
- 1Jin, MingZhao
Antimitotic agents, a class of cancer chemotherapies, target the tubulin protein in microtubules to suppress microtubule dynamics and affect the segregation of chromosomes during cell division. A variety of antimitotic agents are known, which range in status from clinically-approved agents to...
An investigation of factors that regulate cytoskeleton in the first mitotic division of the C. elegans embryoDownload
Microtubule dynamics is regulated by naturally occurring microtubule-associated proteins occurring in the cellular environment as well as by natural and synthetic compounds. These compounds target the microtubule cytoskeleton and serve as anti-mitotic drugs. Therefore, microtubules continue to be...
Microtubules are cellular structures that are crucial to many cellular functions including maintenance of cell shape, vesicular transport, and cell division. The dynamic instability of microtubules is the basic feature which enables them to do their cellular functions. Their pivotal role in cell...
Spindle assembly pathways are conserved in many organisms. Defects in spindle assembly can result in aneuploidy, a common cause of cell death and cancer. A better understanding of spindle assembly pathways is required to fully appreciate how defects in spindle assembly manifest as aneuploidy and...
Three important mechanical behaviors of microtubules in vivo, i.e., buckling, vibration and splitting are investigated with especial focus on their relevance to biological functions of microtubules. To study the vibration and buckling of a microtubule, we model a microtubule as an elastic beam...
The thesis is divided in three parts based largely on published articles or on manuscripts submitted for publication. First we propose a new method which is called the shooting-bead method. This method is a fast and easy experimental technique for evaluating cantilever stiffness and flexural...
In this thesis, we construct a non-local transport model that describes the evolution of microtubules (MTs) as they interact with motor proteins. MTs, whose organization is crucial for normal cellular development, have been found to organize into various patterns in vitro and in vivo through...
Microtubules and Energy Metabolism: Targets for Standard, Combination, and Novel Therapeutic Interventions and Monitoring of CancerDownload
The challenge of understanding and treating cancer has proven to be exceedingly complex. At this juncture, understanding cancer from the perspective of a breakdown of a complex cooperative system using a biophysical analysis may aid in improved treatments and prevention of this disease. In any...