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Environmental Exposures, Gut Microbiota, and Urinary Metabolomic Fingerprint of Crohn’s Disease Patients Who Have Undergone Ileo-colonic Resection
DownloadSpring 2014
Inflammatory bowel disease (IBD) is an idiopathic disease that causes intestinal inflammation and lesions. Canada has one of the highest rates of IBD in the world. One of the major types of IBD is Crohn’s Disease (CD) and a large portion of CD patients will undergo surgical resection in the...
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Fall 2014
Microbiota are ubiquitous in nature. Similarities as well as differences are present between microbiota in animals and fermentation systems. The aim of the PhD project was to investigate factors affects microbial ecology in rodent and sourdough models. To determine how compromised health of the...
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Proliferative Signals Regulate Hemocyte Development and Intestinal Immunity in Drosophila melanogaster.
DownloadSpring 2015
The innate immune system is an ancient line of resistance against intrusive microbial threats. This system integrates cellular, humoral, and barrier defenses to generate a protective immune response. These divisions are indispensable and conserved between Drosophila and mammals. Hemocytes are the...
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The role of starch and fiber composition on nutrient flow, site and extent of nutrient digestion, and microbial profiles in pigs
DownloadSpring 2016
Starch is the main energy substrate for monogastrics, including swine. Physico- chemical properties of starch and the cereal grain matrix can change the kinetics of digestion. Objectives of this thesis were to enhance the understanding of how the physico-chemical properties of purified starch and...
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Understanding the role of Clostridioides difficile and Vitamin D supplementation in shaping the gut microbiome of Canadian infants
DownloadSpring 2019
Introduction: The gut microbiome is shaped during infancy and has an important role in the development of both the immune and metabolic systems. Many early life exposures and events contribute to the composition of this complex intestinal environment, notably early infant diet and breastfeeding....
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Understanding the role of dietary phytochemicals and vitamin B12 in host-microbe interactions to support host gut integrity and health
DownloadSpring 2022
Diet is a strong modifier of gut host-microbe interactions that alter host physiology and immunity against pathogenic bacteria. Some dietary components are required to support host defences that maintain gut homeostasis and symbiosis, whereas others can be detrimental, leading to changes in...