Search
Skip to Search Results- 1Balutis, Andrea M
- 1Bartusiak, Robert
- 1Bentley, Pamela AP
- 1Blanes, Milena S
- 1Ebadi, Maryam
- 1Foroutannaddafi, Aidin
- 11Department of Agricultural, Food, and Nutritional Science
- 2Department of Biological Sciences
- 2Department of Computing Science
- 2Medical Sciences-Laboratory Medicine and Pathology
- 1Department of Cell Biology
- 1Department of Electrical and Computer Engineering
- 2Damaraju, Sambasivarao (Laboratory Medicine and Pathology)
- 1Baracos, Vickie (Oncology)
- 1Belosevic, Miodrag (Biological Sciences)
- 1Catherine Chan (Physiology and Nutrition,Department of Agricultural, Food and Nutritional Science, University of Alberta)
- 1David Wright (Department of human health and nutrition science, University of Guelph
- 1Dinu, Irina (Department of Public Health Sciences)
-
Fall 2012
Mechanisms underlying fat loss in cancer are not well understood. Knowing the types of fat being lost from adipose tissue may help define interventions to circumvent wasting. The aim of this study was to explore the differences in adipokines and fatty acid composition between visceral adipose...
-
Fall 2011
Microarrays are biotechnological advancements measuring expressions of thousands of genes in a single assay. A two-group microarray study yields gene expression measurements for patients with a disease of interest and for healthy controls. Our objective is to apply the methods of microarray data...
-
Application of Next Generation Sequencing and Bioinformatic Approaches to the Study of Influenza Virus Strains and MiRNA Profiling in Liver Diseases
DownloadSpring 2016
Analysis and interpretation of next generation sequencing data has posed a significant challenge to researchers, especially to those who are not equipped with expertise in bioinformatics. In this thesis, I investigated three different biomedical questions using NGS and bioinformatic approaches,...
-
Fall 2014
Optical imaging has long been a gold standard for medical imaging. However, due to the high optical scattering in tissues, it has not been possible to image deeper than a few wavelengths with a useful resolution. Photoacoustic imaging - the use of short-pulsed lasers to induce an ultrasound...
-
Deciphering the molecular mechanisms underlying the pathobiology of esophageal squamous cell carcinoma
DownloadFall 2015
Esophageal squamous cell carcinoma (ESCC) is one of the most lethal cancers worldwide, largely due to a high frequency of tumor invasion/metastasis, chemoresistance and recurrence. In this study, we explored from different perspectives the molecular mechanisms behind these aggressive features of...
-
Detecting, correcting, and preventing the batch effects in multi-site data, with a focus on gene expression Microarrays
DownloadSpring 2014
Gene expression microarrays are widely used to better understand the complex biological mechanisms inside cells. One of the main obstacles of applying statistical learning algorithms to microarray data is the large gap between the number of features (p) and the number of available instances (n),...
-
Elucidating the effects of photoperiod during gestation and lactation on mammary gene expression and function in cows and mice
DownloadSpring 2015
Photoperiod, or day length, generates a highly accurate biological calendar that allows animals to anticipate and adapt to environmental change throughout the year. Photoperiod coordinates both daily and yearly rhythms associated with sleep/wake cycles, behavior, and reproduction, including...
-
Fall 2012
Sub-acute ruminal acidosis is a digestive disorder experienced by animals fed a high grain diet, and causes substantial economic loss to the dairy industry. The objective of this research was to evaluate novel approaches to manage and prevent sub-acute ruminal acidosis. In Study 1, I found that...
-
Spring 2014
Mandatory folate fortification polices in North America have resulted in high levels of circulating folate in the population. At the same time, a trend toward increased energy intake and reduced energy expenditure has lead to an increased prevalence of obesity, characterized by an accumulation of...
-
Fall 2012
The biochemical and molecular mechanisms underlying the beneficial effects of exercise remain elusive. Growing evidence suggests that white adipose tissue (WAT) is an important organ that exercise exerts beneficial effects on. The role of interleukin 6 (IL-6) in mediating WAT metabolism remains...