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Skip to Search Results- 2Fliegel, Larry
- 1Atienza, Bren Jordan Perez
- 1Dibrov, Pavel
- 1Elezzabi, Muhammad A.
- 1Kannan, Rangasayee
- 1Karl, Ry
- 6Graduate and Postdoctoral Studies (GPS), Faculty of
- 6Graduate and Postdoctoral Studies (GPS), Faculty of /Theses and Dissertations
- 2Biochemistry, Department of
- 1Biochemistry, Department of/Journal Articles (Biochemistry)
- 1Biochemistry, Department of/Conference Abstracts and Posters (Biochemistry)
- 1Chemistry, Department of
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Anti-Cancer Mechanism of Trastuzumab via Blocking Nuclear HER2 Function and Epigenetic Mechanism of Resistance
DownloadSpring 2020
HER2 receptor tyrosine kinase (encoded by ERBB2 gene) is overexpressed in approximately 25% of all breast cancer tumors (known as HER2-positive breast cancers). Overexpression of HER2 causes overactivation of downstream receptor tyrosine kinase pathways including PI3K/Akt and MAPK pathways and is...
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Chronic Fatigue Mechanisms in Autoimmune Diseases: Lessons from Primary Biliary Cholangitis and Systemic Sclerosis
DownloadFall 2023
Systemic sclerosis (SSc) is an autoimmune disease affecting the body's connective tissues, resulting in progressive fibrosis and vasculopathy. In some cases, individuals with SSc may also develop primary biliary cholangitis (PBC), another autoimmune disease characterized by damage to their...
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Domino Azide-Metallocarbene Coupling and Nucleophilic Trapping: Synthetic Applications and Mechanistic Studies.
DownloadSpring 2016
Metallocarbenes are a class of reactive intermediates used in many strategic and complementary carbon-carbon and carbon-heteroatom bond forming reactions. The Stevens [1,2]-rearrangement of ammonium ylides is an example of a transformation typically involving metallocarbenes. The replacement of...
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Fall 2023
A thermal-microstructural model was developed to predict the effect of laminar cooling during TMCP on the through thickness microstructure of an X70 steel. Model development was conducted in three sections, beginning with microstructure modelling of dilatometer samples with cooling rates ranging...
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Spring 2019
The formation of bainite is the most studied and the most debated phase transformation in steels, with research spanning almost a century. With two theories of transformation, the transformation mechanism of bainite is still a disputed subject among physical metallurgists. Upper bainite and lower...
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Mitogen-activated protein kinase-dependent activation of the na+/H+ exchanger is mediated through phosphorylation of amino acids ser(770) and ser(771)
Download2007-01-01
Malo, Mackenzie E., Li, Liang, Fliegel, Larry
We investigated regulation of the type 1 isoform of the Na+/H+ exchanger by phosphorylation. Four specific groups of serine and threonine residues in the regulatory carboxyl-terminal tail were mutated to alanine residues: group 1, S693A; group 2, T718A and S723A/S726A/S729A; group 3,...
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Modeling of the Effect of Run-out Table Cooling on the Microstructure of a Thick Walled X70 Skelp
DownloadSpring 2018
This thesis presents work performed to model and measure the effect of run-out table cooling on a thick walled X70 steel. During run-out table cooling, the steel undergoes several phase transformations that will affect its microstructure, and thus, its mechanical properties. To predict the steel...
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Synthesis, characterization, and antibacterial properties of a hydroxyapatite adhesive block copolymer
Download2014-01-01
Zhang, Qiang, Serpe, Michael J.
A novel diblock copolymer composed of bisphosphonate and pyridine oligomers has been prepared by reversible addition–fragmentation transfer (RAFT) polymerization. Ag ion was introduced into the polymer via its coordination with the pyridine groups, followed by a reduction process to obtain Ag...