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Expression and functional significance of the cystic fibrosis transmembrane conductance regulator (CFTR) in human mast cellsDownload
Mast cells (MC) are present in nearly all tissues in the body and participate in many physiological processes including allergy, tissue remodelling, fibrosis, angiogenesis, and autoimmunity. They can be activated by many stimuli, including allergic and innate immune stimulation. When activated,...
Nitric oxide (NO) is a short-lived free radical that plays a critical role in the regulation of cellular signalling. Mast cell (MC) derived NO and exogenous NO regulate MC activities including the inhibition of MC degranulation. At a molecular level the intermediate metabolites of NO modify...
Introduction: Hypertrophic scar (HTS) formation is a fibroproliferative disorder that commonly follows deep dermal burns with prolonged inflammation. It is characterized by excessive extracellular matrix such as collagen deposition mainly by dermal fibroblasts. Mast cells have been implicated in...