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Kidney stones and osteoporosis are prevalent clinical conditions posing a large economic burden to the healthcare system. A common risk factor for both these diseases is hypercalciuria, which is the inappropriate excretion of calcium in urine. Changes in serum calcium levels are detected by the...
Abnormalities in calcium homeostasis can result in kidney stones, a painful and potentially life-threatening condition. Improved therapies for this disorder can only be achieved through increased fundamental knowledge about calcium handling. In the kidneys, filtered calcium (Ca2+) is reabsorbed...