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Cardiomyocyte overexpression of iNOS in mice results in peroxynitrite generation, heart block, and sudden deathDownload
Increased inducible nitric oxide synthase (iNOS) expression is a component of the immune response and has been demonstrated in cardiomyocytes in septic shock, myocarditis, transplant rejection, ischemia, and dilated cardiomyopathy. To explore whether the consequences of such expression are...
Stroke, a reduction in blood flow to the brain, activates various proteins that contribute to neuronal death. The matrix metalloproteinases (MMPs), specifically MMP2 and MMP9, are important in maintaining the blood brain barrier (BBB). After a stroke the BBB permeability increases which is...
Influence of therapeutic hypothermia on neuroprotection and post-ischemic plasticity in a rat model of global ischemiaDownload
Blood flow to the brain may be disrupted by either a stroke (such as focal ischemia or hemorrhage) or cardiac arrest, where the whole brain becomes ischemic. Both forms of injury result in irreversible neuronal loss leading to neurological impairments and a decrease in the quality of life....
Investigating Myocardial PI3Kα Signaling in Models of Ischemia Reperfusion and Cardiotoxic Cancer TherapiesDownload
Background. Phosphoinositide 3-kinase (PI3K) is a lipid kinase that functions as a central intracellular signaling transduction node, receiving input from cell receptors and initiating a cascade of cellular signaling that regulates and integrates central cellular processes such as glucose uptake,...
Cardiovascular and metabolic diseases are still the primary cause of death and disability in modern society. Although genetic factors play a fundamental role in the development of these chronic conditions, the remarkable variability in an individual’s susceptibility to develop these pathologies...
Submitted to the Faculty of Graduate Studies and Research in partial fulfilment of the requirements for the degree of Master of Science, Department of Pediatrics.
The effects of antidepressants on the phenotype of activated microglia and ischemia-injured cortical neuronsDownload
Depression is one of the most common disorders appearing following a stroke and is also a major factor limiting recovery and rehabilitation in stroke patients. Several antidepressants have shown to have anti-inflammatory properties within the central nervous system (CNS). The major source of...
Mild therapeutic hypothermia (HYPO), decreasing brain temperature to 32-35°C, is the gold standard neuroprotectant against ischemia. Cooling also ameliorates several cell death mechanisms in other types of brain injury (e.g., traumatic brain injury). As with many other neuroprotectants, HYPO not...