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Background: Hypertrophic scar (HTS) is a fibroproliferative disorder of the skin that results in the development of painful, red, raised scar lesions. Transforming growth factor beta 1 (TGF-β1) has been implicated as a key driver of this disorder. Primarily, these effects include an increased...
Hypertrophic scars (HTS) are caused by trauma or burn injuries to the deep dermis and can cause cosmetic disfigurement and psychological issues. Our lab has established a human HTS-like nude mouse model, in which the grafted human skin develops red, raised, and firm scarring, resembling...
Background: Dermal fibroproliferative disorders are forms of aberrant cutaneous wound healing, which can lead to the formation of hypertrophic scars (HTS). HTS develop after prolonged healing of deep dermal burns and are associated with excessive inflammation. HTS are characterized by exaggerated...
The Role of Decorin and Factors Influencing its Expression in Wound Healing and Hypertrophic ScarringDownload
Hypertrophic scarring following deep burn injury is a significant problem for many burn patients, and can cause lifelong morbidity including impaired physical function, and reduced psychosocial function from poor cosmesis. While a significant body of research exists, there is still no gold...