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Introduction. Helicobacter pylori infection is an emerging health concern to some northern Canadian Aboriginal communities and their clinicians. Clinicians in the north perceive H. pylori infection to be a major clinical problem because they find H. pylori infection in many patients evaluated for...
Challenges created by data dissemination and access restrictions when attempting to address community concerns: individual privacy versus public wellbeing.Download
Background: Population health data are vital for the identification of public health problems and the development of public health strategies. Challenges arise when attempts are made to disseminate or access anonymised data that are deemed to be potentially identifiable. In these situations,...
Challenges in conducting community-driven research created by differing ways of talking and thinking about science: a researcher’s perspective.Download
Increasingly, health scientists are becoming aware that research collaborations that include community partnerships can be an effective way to broaden the scope and enhance the impact of research aimed at improving public health. Such collaborations extend the reach of academic scientists by...
Developing collaborative research to identify the impacts of Helicobacter pylori genomics research on northern Canadian Indigenous communitiesDownload
SSHRC IDG, funded in 2018 jointly with Genomics Canada. The team has also included the SSHRC Notice of Decision, including ranking and evaluation information. The project seeks to address ethical and cultural challenges related to potential use of genomic data by generating information...
This research determined if alteration of plasma membrane by exogenous gangliosides inhibits Helicobacter pylori adhesion to human gastric epithelial cells. The objective was to evaluate the composition of gangliosides from bovine whole raw milk, bovine colostrum and powder buttermilk using...
Disease manifestations of Helicobacter pylori infection in Arctic Canada: using epidemiology to address community concerns.Download
Objectives Helicobacter pylori infection, linked to gastric cancer, is responsible for a large worldwide disease burden. H pylori prevalence and gastric cancer rates are elevated among indigenous Arctic communities, but implementation of prevention strategies is hampered by insufficient...
The role of environmental exposures in the acquisition of H.pylori and related disease is not yet understood. This analysis examined two hypotheses regarding how environmental exposures may affect digestive health in northern Canada. First, environmental sources of biological contamination may...
Exploiting bacterial glycosylation machineries for the synthesis of a Lewis antigen-containing glycoproteinDownload
Glycoproteins constitute a class of compounds of increasing importance for pharmaceutical applications. The manipulation of bacterial protein glycosylation systems from Gram-negative bacteria for the synthesis of recombinant glycoproteins is a promising alternative to the current production...
Liposome-based therapy: An alternative approach to treat Helicobacter pylori infection in high prevalence communities such as Aklavik, NWTDownload
Helicobacter pylori infects about half of the world population causing chronic gastritis, peptic ulcer or gastric cancer. The Aboriginal people in Aklavik, NWT, Canada are concerned about gastric cancer because of the high prevalence of H. pylori infection (58%) in their community. H. pylori...
Whose burden? A comprehensive approach to describing burden of disease by synthesizing evidence from diverse perspectivesDownload
Epidemiologists tasked with addressing public concerns about a specific health issue and developing effective public health strategies aimed at reducing related health risks must begin by describing the extent of the health threat in the target population. Typical approaches use quantitative...